1scm

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(New page: 200px<br /><applet load="1scm" size="450" color="white" frame="true" align="right" spinBox="true" caption="1scm, resolution 2.8&Aring;" /> '''STRUCTURE OF THE REGU...)
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[[Image:1scm.gif|left|200px]]<br /><applet load="1scm" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1scm, resolution 2.8&Aring;" />
 
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'''STRUCTURE OF THE REGULATORY DOMAIN OF SCALLOP MYOSIN AT 2.8 ANGSTROMS RESOLUTION'''<br />
 
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==Overview==
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==STRUCTURE OF THE REGULATORY DOMAIN OF SCALLOP MYOSIN AT 2.8 ANGSTROMS RESOLUTION==
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The regulatory domain of scallop myosin is a three-chain protein complex, that switches on this motor in response to Ca2+ binding. This domain has, been crystallized and the structure solved to 2.8 A resolution. Side-chain, interactions link the two light chains in tandem to adjacent segments of, the heavy chain bearing the IQ-sequence motif. The Ca(2+)-binding site is, a novel EF-hand motif on the essential light chain and is stabilized by, linkages involving the heavy chain and both light chains, accounting for, the requirement of all three chains for Ca2+ binding and regulation in the, intact myosin molecule.
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<StructureSection load='1scm' size='340' side='right'caption='[[1scm]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1scm]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Argopecten_irradians Argopecten irradians]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SCM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SCM FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1scm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1scm OCA], [https://pdbe.org/1scm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1scm RCSB], [https://www.ebi.ac.uk/pdbsum/1scm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1scm ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MYS_ARGIR MYS_ARGIR] Muscle contraction. Myosin is a protein that binds to F-actin and has ATPase activity that is activated by F-actin.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sc/1scm_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1scm ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1SCM is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Argopecten_irradians Argopecten irradians] with CA as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1SCM OCA].
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*[[Myosin 3D Structures|Myosin 3D Structures]]
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__TOC__
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==Reference==
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</StructureSection>
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Structure of the regulatory domain of scallop myosin at 2.8 A resolution., Xie X, Harrison DH, Schlichting I, Sweet RM, Kalabokis VN, Szent-Gyorgyi AG, Cohen C, Nature. 1994 Mar 24;368(6469):306-12. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8127365 8127365]
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[[Category: Argopecten irradians]]
[[Category: Argopecten irradians]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Cohen, C.]]
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[[Category: Cohen C]]
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[[Category: Xie, X.]]
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[[Category: Xie X]]
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[[Category: CA]]
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[[Category: calcium-binding protein]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 02:16:35 2007''
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Current revision

STRUCTURE OF THE REGULATORY DOMAIN OF SCALLOP MYOSIN AT 2.8 ANGSTROMS RESOLUTION

PDB ID 1scm

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