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1sdd

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(New page: 200px<br /><applet load="1sdd" size="450" color="white" frame="true" align="right" spinBox="true" caption="1sdd, resolution 2.8&Aring;" /> '''Crystal Structure of ...)
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[[Image:1sdd.gif|left|200px]]<br /><applet load="1sdd" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1sdd, resolution 2.8&Aring;" />
 
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'''Crystal Structure of Bovine Factor Vai'''<br />
 
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==Overview==
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==Crystal Structure of Bovine Factor Vai==
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In vertebrate hemostasis, factor Va serves as the cofactor in the, prothrombinase complex that results in a 300,000-fold increase in the rate, of thrombin generation compared with factor Xa alone. Structurally, little, is known about the mechanism by which factor Va alters catalysis within, this complex. Here, we report a crystal structure of protein C inactivated, factor Va (A1.A3-C1-C2) that depicts a previously uncharacterized domain, arrangement. This orientation has implications for binding to membranes, essential for function. A high-affinity calcium-binding site and a, copper-binding site have both been identified. Surprisingly, neither shows, a direct involvement in chain association. This structure represents the, largest physiologically relevant fragment of factor Va solved to date and, provides a new scaffold for the future generation of models of coagulation, cofactors.
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<StructureSection load='1sdd' size='340' side='right'caption='[[1sdd]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1sdd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SDD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SDD FirstGlance]. <br>
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1SDD is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with NAG, NDG, CU and CA as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1SDD OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sdd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sdd OCA], [https://pdbe.org/1sdd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sdd RCSB], [https://www.ebi.ac.uk/pdbsum/1sdd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sdd ProSAT]</span></td></tr>
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The crystal structure of activated protein C-inactivated bovine factor Va: Implications for cofactor function., Adams TE, Hockin MF, Mann KG, Everse SJ, Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):8918-23. Epub 2004 Jun 7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15184653 15184653]
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FA5_BOVIN FA5_BOVIN] Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sd/1sdd_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sdd ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Adams, T.E.]]
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[[Category: Adams TE]]
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[[Category: Everse, S.J.]]
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[[Category: Everse SJ]]
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[[Category: Hockin, M.F.]]
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[[Category: Hockin MF]]
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[[Category: Mann, K.G.]]
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[[Category: Mann KG]]
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[[Category: CA]]
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[[Category: CU]]
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[[Category: NAG]]
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[[Category: NDG]]
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[[Category: coagulation]]
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[[Category: cofactor]]
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[[Category: copper-binding protein]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 02:17:52 2007''
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Current revision

Crystal Structure of Bovine Factor Vai

PDB ID 1sdd

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