2dlm
From Proteopedia
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| - | {{Seed}} | ||
| - | [[Image:2dlm.png|left|200px]] | ||
| - | + | ==Solution structure of the first SH3 domain of human vinexin== | |
| - | + | <StructureSection load='2dlm' size='340' side='right'caption='[[2dlm]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2dlm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DLM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DLM FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dlm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dlm OCA], [https://pdbe.org/2dlm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dlm RCSB], [https://www.ebi.ac.uk/pdbsum/2dlm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dlm ProSAT], [https://www.topsan.org/Proteins/RSGI/2dlm TOPSAN]</span></td></tr> | |
| - | + | </table> | |
| - | + | == Function == | |
| - | + | [https://www.uniprot.org/uniprot/VINEX_HUMAN VINEX_HUMAN] Vinexin alpha isoform promotes up-regulation of actin stress fiber formation. Vinexin beta isoform plays a role in cell spreading and enhances the activation of JNK/SAPK in response to EGF stimulation by using its third SH3 domain. | |
| - | + | == Evolutionary Conservation == | |
| - | + | [[Image:Consurf_key_small.gif|200px|right]] | |
| - | == | + | Check<jmol> |
| - | + | <jmolCheckbox> | |
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dl/2dlm_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dlm ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Hayashi | + | [[Category: Hayashi F]] |
| - | [[Category: Izumi | + | [[Category: Izumi K]] |
| - | + | [[Category: Yokoyama S]] | |
| - | [[Category: Yokoyama | + | [[Category: Yoshida M]] |
| - | [[Category: Yoshida | + | [[Category: Zhang HP]] |
| - | [[Category: Zhang | + | |
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Current revision
Solution structure of the first SH3 domain of human vinexin
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