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1shs

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(New page: 200px<br /><applet load="1shs" size="450" color="white" frame="true" align="right" spinBox="true" caption="1shs, resolution 2.9&Aring;" /> '''SMALL HEAT SHOCK PROT...)
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[[Image:1shs.gif|left|200px]]<br /><applet load="1shs" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1shs, resolution 2.9&Aring;" />
 
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'''SMALL HEAT SHOCK PROTEIN FROM METHANOCOCCUS JANNASCHII'''<br />
 
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==Overview==
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==SMALL HEAT SHOCK PROTEIN FROM METHANOCOCCUS JANNASCHII==
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The principal heat-shock proteins that have chaperone activity (that is, they protect newly made proteins from misfolding) belong to five conserved, classes: HSP100, HSP90, HSP70, HSP60 and the small heat-shock proteins, (sHSPs). The sHSPs can form large multimeric structures and have a wide, range of cellular functions, including endowing cells with thermotolerance, in vivo and being able to act as molecular chaperones in vitro; sHSPs do, this by forming stable complexes with folding intermediates of their, protein substrates. However, there is little information available about, these structures or the mechanism by which substrates are protected from, thermal denaturation by sHSPs. Here we report the crystal structure of a, small heat-shock protein from Methanococcus jannaschii, a, hyperthermophilic archaeon. The monomeric folding unit is a composite, beta-sandwich in which one of the beta-strands comes from a neighbouring, molecule. Twenty-four monomers form a hollow spherical complex of, octahedral symmetry, with eight trigonal and six square 'windows'. The, sphere has an outer diameter of 120 A and an inner diameter of 65 A.
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<StructureSection load='1shs' size='340' side='right'caption='[[1shs]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1shs]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SHS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SHS FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1shs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1shs OCA], [https://pdbe.org/1shs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1shs RCSB], [https://www.ebi.ac.uk/pdbsum/1shs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1shs ProSAT], [https://www.topsan.org/Proteins/BSGC/1shs TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HSPS_METJA HSPS_METJA] Chaperone that confers thermal protection to other proteins.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sh/1shs_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1shs ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1SHS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1SHS OCA].
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*[[Heat Shock Protein structures|Heat Shock Protein structures]]
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__TOC__
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==Reference==
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</StructureSection>
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Crystal structure of a small heat-shock protein., Kim KK, Kim R, Kim SH, Nature. 1998 Aug 6;394(6693):595-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9707123 9707123]
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[[Category: Large Structures]]
[[Category: Methanocaldococcus jannaschii]]
[[Category: Methanocaldococcus jannaschii]]
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[[Category: Single protein]]
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[[Category: Kim KK]]
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[[Category: BSGC, Berkeley.Structural.Genomics.Center.]]
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[[Category: Kim R]]
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[[Category: Kim, K.K.]]
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[[Category: Kim SH]]
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[[Category: Kim, R.]]
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[[Category: Kim, S.H.]]
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[[Category: berkeley structural genomics center]]
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[[Category: beta-sandwich]]
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[[Category: bsgc]]
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[[Category: chaperone]]
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[[Category: heat shock protein]]
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[[Category: protein structure initiative]]
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[[Category: psi]]
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[[Category: structural genomics]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 02:23:37 2007''
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Current revision

SMALL HEAT SHOCK PROTEIN FROM METHANOCOCCUS JANNASCHII

PDB ID 1shs

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