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2j4k

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(New page: 200px<br /> <applet load="2j4k" size="450" color="white" frame="true" align="right" spinBox="true" caption="2j4k, resolution 2.20&Aring;" /> '''CRYSTAL STRUCTURE O...)
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[[Image:2j4k.gif|left|200px]]<br />
 
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<applet load="2j4k" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="2j4k, resolution 2.20&Aring;" />
 
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'''CRYSTAL STRUCTURE OF URIDYLATE KINASE FROM SULFOLOBUS SOLFATARICUS IN COMPLEX WITH UMP TO 2.2 ANGSTROM RESOLUTION'''<br />
 
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==About this Structure==
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==Crystal structure of uridylate kinase from Sulfolobus solfataricus in complex with UMP to 2.2 Angstrom resolution==
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2J4K is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]] with CD, MG and U5P as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.22 2.7.4.22]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2J4K OCA]].
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<StructureSection load='2j4k' size='340' side='right'caption='[[2j4k]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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[[Category: Single protein]]
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== Structural highlights ==
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[[Category: Sulfolobus solfataricus]]
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<table><tr><td colspan='2'>[[2j4k]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus_P2 Saccharolobus solfataricus P2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J4K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J4K FirstGlance]. <br>
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[[Category: Jensen, K.F.]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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[[Category: Jensen, K.S.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=U5P:URIDINE-5-MONOPHOSPHATE'>U5P</scene></td></tr>
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[[Category: Johansson, E.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j4k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j4k OCA], [https://pdbe.org/2j4k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j4k RCSB], [https://www.ebi.ac.uk/pdbsum/2j4k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j4k ProSAT]</span></td></tr>
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[[Category: CD]]
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</table>
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[[Category: MG]]
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== Function ==
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[[Category: U5P]]
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[https://www.uniprot.org/uniprot/PYRH_SACS2 PYRH_SACS2] Catalyzes the reversible phosphorylation of UMP to UDP, with ATP as the most efficient phosphate donor. Is also able to phosphorylate dUMP, although much less efficiently.<ref>PMID:17297917</ref>
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[[Category: aspartokinase family]]
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== Evolutionary Conservation ==
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[[Category: kinase]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: nucleoside monophosphate kinase]]
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Check<jmol>
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[[Category: pyrimidine biosynthesis]]
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<jmolCheckbox>
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[[Category: pyrimidine nucleotide synthesis]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j4/2j4k_consurf.spt"</scriptWhenChecked>
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[[Category: transferase]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: ump kinase]]
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2j4k ConSurf].
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<div style="clear:both"></div>
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 21:02:56 2007''
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==See Also==
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*[[Uridylate kinase|Uridylate kinase]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Saccharolobus solfataricus P2]]
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[[Category: Jensen KF]]
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[[Category: Jensen KS]]
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[[Category: Johansson E]]

Current revision

Crystal structure of uridylate kinase from Sulfolobus solfataricus in complex with UMP to 2.2 Angstrom resolution

PDB ID 2j4k

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