This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2cp9

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (11:28, 22 May 2024) (edit) (undo)
 
(11 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:2cp9.png|left|200px]]
 
-
<!--
+
==Solution structure of RSGI RUH-042, a UBA domain from human mitochondrial elongation factor Ts==
-
The line below this paragraph, containing "STRUCTURE_2cp9", creates the "Structure Box" on the page.
+
<StructureSection load='2cp9' size='340' side='right'caption='[[2cp9]]' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2cp9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CP9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CP9 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cp9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cp9 OCA], [https://pdbe.org/2cp9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cp9 RCSB], [https://www.ebi.ac.uk/pdbsum/2cp9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cp9 ProSAT], [https://www.topsan.org/Proteins/RSGI/2cp9 TOPSAN]</span></td></tr>
-
{{STRUCTURE_2cp9| PDB=2cp9 | SCENE= }}
+
</table>
 +
== Disease ==
 +
[https://www.uniprot.org/uniprot/EFTS_HUMAN EFTS_HUMAN] Defects in TSFM are the cause of combined oxidative phosphorylation deficiency type 3 (COXPD3) [MIM:[https://omim.org/entry/610505 610505]. Defects in the mitochondrial oxidative phosphorylation system result in devastating, mainly multisystem, diseases. COXPD3 symptoms include severe metabolic acidosis with encephalomyopathy or with hypertrophic cardiomyopathy. Patients show a severe defect in mitochondrial translation leading to a failure to assemble adequate amounts of three of the oxidative phosphorylation complexes.<ref>PMID:17033963</ref>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/EFTS_HUMAN EFTS_HUMAN] Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity).[HAMAP-Rule:MF_03135]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cp/2cp9_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cp9 ConSurf].
 +
<div style="clear:both"></div>
-
===Solution structure of RSGI RUH-042, a UBA domain from human mitochondrial elongation factor Ts===
+
==See Also==
-
 
+
*[[Elongation factor 3D structures|Elongation factor 3D structures]]
-
 
+
== References ==
-
==About this Structure==
+
<references/>
-
2CP9 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CP9 OCA].
+
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Hirota, H.]]
+
[[Category: Hirota H]]
-
[[Category: Izumi, K.]]
+
[[Category: Izumi K]]
-
[[Category: Ohashi, W.]]
+
[[Category: Ohashi W]]
-
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
+
[[Category: Yokoyama S]]
-
[[Category: Yokoyama, S.]]
+
[[Category: Yoshida M]]
-
[[Category: Yoshida, M.]]
+
-
[[Category: Human]]
+
-
[[Category: National project on protein structural and functional analyse]]
+
-
[[Category: Nppsfa]]
+
-
[[Category: Riken structural genomics/proteomics initiative]]
+
-
[[Category: Rsgi]]
+
-
[[Category: Structural genomic]]
+
-
[[Category: Uba]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Sep 29 06:02:53 2008''
+

Current revision

Solution structure of RSGI RUH-042, a UBA domain from human mitochondrial elongation factor Ts

PDB ID 2cp9

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2cp9"
Personal tools