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1srx

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(New page: 200px<br /><applet load="1srx" size="450" color="white" frame="true" align="right" spinBox="true" caption="1srx, resolution 2.8&Aring;" /> '''THREE-DIMENSIONAL STR...)
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[[Image:1srx.gif|left|200px]]<br /><applet load="1srx" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1srx, resolution 2.8&Aring;" />
 
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'''THREE-DIMENSIONAL STRUCTURE OF ESCHERICHIA COLI THIOREDOXIN-S2 TO 2.8 ANGSTROMS RESOLUTION'''<br />
 
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==Overview==
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==THREE-DIMENSIONAL STRUCTURE OF ESCHERICHIA COLI THIOREDOXIN-S2 TO 2.8 ANGSTROMS RESOLUTION==
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The three-dimensional structure of the electron transport protein, thioredoxin-S2 from E. coli has been determined from a 2.8 A resolution, electron density map. The molecule is built up of a central core of three, parallel and two antiparallel strands of pleated sheet surrounded by four, helices. Thr residues involved in the active center 14-membered disulfide, ring of thioredoxin form a protrusion between one of the helices and the, middle strand of the pleated sheet. This region of the molecule, comprising two parallel strands joined by the protrusion and a helix, is, structurally very similar to corresponding functionally important regions, in the nucleotide-binding domains of flavodoxin and the dehydrogenases., The molecule has about 75% of the residues in well-defined secondary, structures. The structure indicates that the carboxy-terminal third of the, molecule forms an independent folding unit consisting of two strands of, antiparallel pleated sheet and a terminal alpha-helix. This agress with, the noncovalent reconstitution experiments from thioredoxin peptide, fragments. Thioredoxin is an example of a protein with the active center, located on a protrusion rather than in a cleft, thus demonstrating the, existence of male proteins.
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<StructureSection load='1srx' size='340' side='right'caption='[[1srx]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1srx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_B Escherichia coli B]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SRX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SRX FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1srx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1srx OCA], [https://pdbe.org/1srx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1srx RCSB], [https://www.ebi.ac.uk/pdbsum/1srx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1srx ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/THIO_ECOLI THIO_ECOLI] Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sr/1srx_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1srx ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1SRX is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_b Escherichia coli b]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1SRX OCA].
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*[[Thioredoxin 3D structures|Thioredoxin 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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Three-dimensional structure of Escherichia coli thioredoxin-S2 to 2.8 A resolution., Holmgren A, Soderberg BO, Eklund H, Branden CI, Proc Natl Acad Sci U S A. 1975 Jun;72(6):2305-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=1094461 1094461]
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[[Category: Escherichia coli B]]
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[[Category: Escherichia coli b]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Soderberg B-O]]
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[[Category: Soderberg, B.O.]]
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[[Category: electron transport]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 02:36:56 2007''
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Current revision

THREE-DIMENSIONAL STRUCTURE OF ESCHERICHIA COLI THIOREDOXIN-S2 TO 2.8 ANGSTROMS RESOLUTION

PDB ID 1srx

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