2css

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{{Seed}}
 
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[[Image:2css.png|left|200px]]
 
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<!--
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==Solution structure of the PDZ domain of human KIAA0340 protein==
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The line below this paragraph, containing "STRUCTURE_2css", creates the "Structure Box" on the page.
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<StructureSection load='2css' size='340' side='right'caption='[[2css]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2css]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CSS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CSS FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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-->
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2css FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2css OCA], [https://pdbe.org/2css PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2css RCSB], [https://www.ebi.ac.uk/pdbsum/2css PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2css ProSAT], [https://www.topsan.org/Proteins/RSGI/2css TOPSAN]</span></td></tr>
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{{STRUCTURE_2css| PDB=2css | SCENE= }}
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</table>
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== Disease ==
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===Solution structure of the PDZ domain of human KIAA0340 protein===
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[https://www.uniprot.org/uniprot/RIMS1_HUMAN RIMS1_HUMAN] Defects in RIMS1 may be a cause of cone-rod dystrophy type 7 (CORD7) [MIM:[https://omim.org/entry/603649 603649]. CORDs are inherited retinal dystrophies belonging to the group of pigmentary retinopathies. CORDs are characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa.<ref>PMID:12659814</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/RIMS1_HUMAN RIMS1_HUMAN] Rab effector involved in exocytosis. May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity (By similarity).
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==About this Structure==
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== Evolutionary Conservation ==
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2CSS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CSS OCA].
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cs/2css_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2css ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Hayashi, F.]]
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[[Category: Hayashi F]]
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[[Category: Inoue, K.]]
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[[Category: Inoue K]]
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[[Category: Qin, X R.]]
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[[Category: Qin X-R]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Yokoyama S]]
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[[Category: Yokoyama, S.]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Pdz domain]]
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[[Category: Rab3-interacting molecule 1]]
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[[Category: Regulating synaptic membrane exocytosis protein 1]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rim 1]]
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[[Category: Rsgi]]
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[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Sep 29 07:32:43 2008''
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Current revision

Solution structure of the PDZ domain of human KIAA0340 protein

PDB ID 2css

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

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