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1dp4

From Proteopedia

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{{Seed}}
 
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[[Image:1dp4.png|left|200px]]
 
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<!--
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==DIMERIZED HORMONE BINDING DOMAIN OF THE ATRIAL NATRIURETIC PEPTIDE RECEPTOR==
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The line below this paragraph, containing "STRUCTURE_1dp4", creates the "Structure Box" on the page.
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<StructureSection load='1dp4' size='340' side='right'caption='[[1dp4]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1dp4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DP4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DP4 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_1dp4| PDB=1dp4 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dp4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dp4 OCA], [https://pdbe.org/1dp4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dp4 RCSB], [https://www.ebi.ac.uk/pdbsum/1dp4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dp4 ProSAT]</span></td></tr>
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</table>
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===DIMERIZED HORMONE BINDING DOMAIN OF THE ATRIAL NATRIURETIC PEPTIDE RECEPTOR===
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== Function ==
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[https://www.uniprot.org/uniprot/ANPRA_RAT ANPRA_RAT] Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand (By similarity).
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== Evolutionary Conservation ==
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<!--
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_10894551}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 10894551 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dp/1dp4_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_10894551}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1DP4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DP4 OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dp4 ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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Structure of the dimerized hormone-binding domain of a guanylyl-cyclase-coupled receptor., van den Akker F, Zhang X, Miyagi M, Huo X, Misono KS, Yee VC, Nature. 2000 Jul 6;406(6791):101-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10894551 10894551]
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</StructureSection>
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[[Category: Guanylate cyclase]]
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[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Single protein]]
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[[Category: Huo X]]
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[[Category: Akker, F van den.]]
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[[Category: Misono KS]]
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[[Category: Huo, X.]]
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[[Category: Miyagi M]]
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[[Category: Misono, K S.]]
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[[Category: Yee VC]]
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[[Category: Miyagi, M.]]
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[[Category: Zhang X]]
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[[Category: Yee, V C.]]
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[[Category: Van den Akker F]]
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[[Category: Zhang, X.]]
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[[Category: Dimer]]
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[[Category: Hormone/growth factor receptor]]
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[[Category: Lyase complex]]
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[[Category: Periplasmic binding protein fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 1 20:17:35 2008''
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Current revision

DIMERIZED HORMONE BINDING DOMAIN OF THE ATRIAL NATRIURETIC PEPTIDE RECEPTOR

PDB ID 1dp4

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