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2k8m
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 2k8m is ON HOLD Authors: Mohan, S.K., Rani, S.G., Kumor, S.M., Yu, C. Description: S100A13-C2A ''Page seeded by [http://oca.weizmann.ac.il/oca OCA...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==S100A13-C2A binary complex structure== | |
| + | <StructureSection load='2k8m' size='340' side='right'caption='[[2k8m]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2k8m]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K8M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K8M FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k8m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k8m OCA], [https://pdbe.org/2k8m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k8m RCSB], [https://www.ebi.ac.uk/pdbsum/2k8m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k8m ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/SYT1_HUMAN SYT1_HUMAN] May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k8/2k8m_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2k8m ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | + | ==See Also== | |
| - | + | *[[S100 proteins 3D structures|S100 proteins 3D structures]] | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | [[Category: Homo sapiens]] | |
| + | [[Category: Large Structures]] | ||
| + | [[Category: Kumar SM]] | ||
| + | [[Category: Mohan SK]] | ||
| + | [[Category: Rani SG]] | ||
| + | [[Category: Yu C]] | ||
Current revision
S100A13-C2A binary complex structure
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Categories: Homo sapiens | Large Structures | Kumar SM | Mohan SK | Rani SG | Yu C
