1sui

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(New page: 200px<br /><applet load="1sui" size="450" color="white" frame="true" align="right" spinBox="true" caption="1sui, resolution 2.70&Aring;" /> '''Alfalfa caffeoyl coe...)
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[[Image:1sui.gif|left|200px]]<br /><applet load="1sui" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1sui, resolution 2.70&Aring;" />
 
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'''Alfalfa caffeoyl coenzyme A 3-O-methyltransferase'''<br />
 
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==Overview==
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==Alfalfa caffeoyl coenzyme A 3-O-methyltransferase==
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Caffeoyl coenzyme A 3-O-methyltransferases (CCoAOMTs) are, S-adenosyl-l-methionine-dependent O-methyltransferases (OMTs) involved in, lignin biosynthesis. Plant CCoAOMTs belong to a distinct family of OMTs, more closely related to the mammalian catechol OMTs than to other plant, OMTs. The crystal structure of alfalfa (Medicago sativa) CCoAOMT in, complex with the reaction products S-adenosine-l-homocysteine and, feruloyl/sinapoyl CoAs presented here belong to a structurally and, mechanistically distinct family of plant small molecule OMTs. These, structures provide a new understanding of the substrate preferences and, the catalytic mechanism accompanying CCoAOMT-mediated O-methylation of, CoA-linked phenylpropanoid substrates.
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<StructureSection load='1sui' size='340' side='right'caption='[[1sui]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1sui]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Medicago_sativa Medicago sativa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SUI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SUI FirstGlance]. <br>
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1SUI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Medicago_sativa Medicago sativa] with CA, SAH and FRE as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Caffeoyl-CoA_O-methyltransferase Caffeoyl-CoA O-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.104 2.1.1.104] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1SUI OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FRE:FERULOYL+COENZYME+A'>FRE</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sui FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sui OCA], [https://pdbe.org/1sui PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sui RCSB], [https://www.ebi.ac.uk/pdbsum/1sui PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sui ProSAT]</span></td></tr>
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Crystal structures of alfalfa caffeoyl coenzyme A 3-O-methyltransferase., Ferrer JL, Zubieta C, Dixon RA, Noel JP, Plant Physiol. 2005 Mar;137(3):1009-17. Epub 2005 Feb 25. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15734921 15734921]
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</table>
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[[Category: Caffeoyl-CoA O-methyltransferase]]
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== Function ==
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[https://www.uniprot.org/uniprot/CAMT_MEDSA CAMT_MEDSA] Methylates caffeoyl-CoA to feruloyl-CoA and 5-hydroxyferuloyl-CoA to sinapoyl-CoA. Plays a role in the synthesis of feruloylated polysaccharides. Involved in the reinforcement of the plant cell wall. Also involved in the responding to wounding or pathogen challenge by the increased formation of cell wall-bound ferulic acid polymers.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/su/1sui_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sui ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Medicago sativa]]
[[Category: Medicago sativa]]
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[[Category: Single protein]]
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[[Category: Dixon RA]]
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[[Category: Dixon, R.A.]]
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[[Category: Ferrer J-L]]
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[[Category: Ferrer, J.L.]]
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[[Category: Noel JP]]
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[[Category: Noel, J.P.]]
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[[Category: Zubieta C]]
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[[Category: Zubieta, C.]]
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[[Category: CA]]
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[[Category: FRE]]
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[[Category: SAH]]
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[[Category: protein-cofactor-substrate complex]]
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[[Category: rossmann fold]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 02:40:55 2007''
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Current revision

Alfalfa caffeoyl coenzyme A 3-O-methyltransferase

PDB ID 1sui

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