2rd3
From Proteopedia
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| - | {{Seed}} | ||
| - | [[Image:2rd3.jpg|left|200px]] | ||
| - | + | ==Crystal structure of TenA homologue (HP1287) from Helicobacter pylori== | |
| - | + | <StructureSection load='2rd3' size='340' side='right'caption='[[2rd3]], [[Resolution|resolution]] 2.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2rd3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori_NCTC_11637_=_CCUG_17874_=_ATCC_43504_=_JCM_12093 Helicobacter pylori NCTC 11637 = CCUG 17874 = ATCC 43504 = JCM 12093]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RD3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RD3 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7Å</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rd3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rd3 OCA], [https://pdbe.org/2rd3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rd3 RCSB], [https://www.ebi.ac.uk/pdbsum/2rd3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rd3 ProSAT]</span></td></tr> | |
| - | + | </table> | |
| - | + | == Function == | |
| - | + | [https://www.uniprot.org/uniprot/TENA_HELPX TENA_HELPX] Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds to give a hydroxymethylpyrimidine (HMP). Displays low activity on 4-amino-5-aminomethyl-2-methylpyrimidine as substrate, indicating that the enzyme may act on a different HMP precursor that may derive from the human stomach food assumption or processing. Is probably involved in thiamine biosynthesis. Does not display thiaminase II activity, as it is unable to hydrolyze thiamine.<ref>PMID:19780837</ref> | |
| - | + | == Evolutionary Conservation == | |
| - | + | [[Image:Consurf_key_small.gif|200px|right]] | |
| - | == | + | Check<jmol> |
| - | + | <jmolCheckbox> | |
| - | [ | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rd/2rd3_consurf.spt"</scriptWhenChecked> |
| - | [[ | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> |
| - | [[ | + | <text>to colour the structure by Evolutionary Conservation</text> |
| - | [[ | + | </jmolCheckbox> |
| - | [[ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rd3 ConSurf]. |
| - | [ | + | <div style="clear:both"></div> |
| - | [[ | + | == References == |
| - | [ | + | <references/> |
| - | [[ | + | __TOC__ |
| - | [ | + | </StructureSection> |
| - | [[Category: | + | [[Category: Helicobacter pylori NCTC 11637 = CCUG 17874 = ATCC 43504 = JCM 12093]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Angelini A]] |
| - | [[Category: | + | [[Category: Barison N]] |
| - | [[Category: | + | [[Category: Cendron L]] |
| - | [[Category: | + | [[Category: Trento A]] |
| - | + | [[Category: Zanotti G]] | |
| - | + | ||
Current revision
Crystal structure of TenA homologue (HP1287) from Helicobacter pylori
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