2af0

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{{Seed}}
 
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[[Image:2af0.png|left|200px]]
 
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==Structure of the Regulator of G-Protein Signaling Domain of RGS2==
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The line below this paragraph, containing "STRUCTURE_2af0", creates the "Structure Box" on the page.
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<StructureSection load='2af0' size='340' side='right'caption='[[2af0]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2af0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AF0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AF0 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2af0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2af0 OCA], [https://pdbe.org/2af0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2af0 RCSB], [https://www.ebi.ac.uk/pdbsum/2af0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2af0 ProSAT]</span></td></tr>
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{{STRUCTURE_2af0| PDB=2af0 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RGS2_HUMAN RGS2_HUMAN] Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. May play a role in leukemogenesis. Plays a role in negative feedback control pathway for adenylyl cyclase signaling. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein.<ref>PMID:11278586</ref> <ref>PMID:17901199</ref> <ref>PMID:7643615</ref> <ref>PMID:19736320</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/af/2af0_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2af0 ConSurf].
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<div style="clear:both"></div>
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===Structure of the Regulator of G-Protein Signaling Domain of RGS2===
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==See Also==
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*[[Regulator of G-protein signaling 3D structures|Regulator of G-protein signaling 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_18434541}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 18434541 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_18434541}}
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==About this Structure==
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2AF0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AF0 OCA].
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==Reference==
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Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits., Soundararajan M, Willard FS, Kimple AJ, Turnbull AP, Ball LJ, Schoch GA, Gileadi C, Fedorov OY, Dowler EF, Higman VA, Hutsell SQ, Sundstrom M, Doyle DA, Siderovski DP, Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6457-62. Epub 2008 Apr 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18434541 18434541]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C.]]
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[[Category: Arrowsmith C]]
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[[Category: Delft, F Von.]]
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[[Category: Doyle DA]]
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[[Category: Doyle, D A.]]
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[[Category: Edwards A]]
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[[Category: Edwards, A.]]
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[[Category: Elkins JM]]
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[[Category: Elkins, J M.]]
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[[Category: Johannson C]]
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[[Category: Johannson, C.]]
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[[Category: Papagrigoriou E]]
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[[Category: Papagrigoriou, E.]]
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[[Category: Phillips C]]
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[[Category: Phillips, C.]]
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[[Category: Smee C]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Sundstrom M]]
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[[Category: Smee, C.]]
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[[Category: Von Delft F]]
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[[Category: Sundstrom, M.]]
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[[Category: Weigelt J]]
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[[Category: Weigelt, J.]]
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[[Category: Helix]]
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[[Category: Sgc]]
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[[Category: Signaling protein]]
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[[Category: Structural genomic]]
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[[Category: Structural genomics consortium]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 1 21:48:52 2008''
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Current revision

Structure of the Regulator of G-Protein Signaling Domain of RGS2

PDB ID 2af0

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