2a72

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{{Seed}}
 
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[[Image:2a72.png|left|200px]]
 
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==Structure of the regulator of G-protein signaling domain of RGS7==
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The line below this paragraph, containing "STRUCTURE_2a72", creates the "Structure Box" on the page.
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<StructureSection load='2a72' size='340' side='right'caption='[[2a72]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2a72]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A72 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A72 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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{{STRUCTURE_2a72| PDB=2a72 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a72 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a72 OCA], [https://pdbe.org/2a72 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a72 RCSB], [https://www.ebi.ac.uk/pdbsum/2a72 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a72 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RGS7_HUMAN RGS7_HUMAN] Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(o)-alpha is specifically enhanced by the RGS6/GNG5 dimer. May play a role in synaptic vesicle exocytosis. May play important role in the rapid regulation of neuronal excitability and the cellular responses to short-lived stimulations (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a7/2a72_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2a72 ConSurf].
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<div style="clear:both"></div>
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===Structure of the regulator of G-protein signaling domain of RGS7===
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==See Also==
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*[[Regulator of G-protein signaling 3D structures|Regulator of G-protein signaling 3D structures]]
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__TOC__
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 18434541 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18434541}}
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==About this Structure==
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2A72 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A72 OCA].
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==Reference==
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Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits., Soundararajan M, Willard FS, Kimple AJ, Turnbull AP, Ball LJ, Schoch GA, Gileadi C, Fedorov OY, Dowler EF, Higman VA, Hutsell SQ, Sundstrom M, Doyle DA, Siderovski DP, Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6457-62. Epub 2008 Apr 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18434541 18434541]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C.]]
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[[Category: Arrowsmith C]]
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[[Category: Debreczeni, J.]]
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[[Category: Debreczeni J]]
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[[Category: Delft, F von.]]
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[[Category: Doyle DA]]
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[[Category: Doyle, D A.]]
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[[Category: Edwards A]]
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[[Category: Edwards, A.]]
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[[Category: Elkins JM]]
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[[Category: Elkins, J M.]]
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[[Category: Gileadi O]]
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[[Category: Gileadi, O.]]
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[[Category: Johansson C]]
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[[Category: Johansson, C.]]
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[[Category: Phillips C]]
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[[Category: Phillips, C.]]
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[[Category: Schoch GA]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Smee C]]
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[[Category: Schoch, G A.]]
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[[Category: Sundstrom M]]
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[[Category: Smee, C.]]
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[[Category: Von Delft F]]
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[[Category: Sundstrom, M.]]
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[[Category: Human rgs7]]
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[[Category: Regulator of g-protein signaling 7]]
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[[Category: Sgc]]
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[[Category: Signaling protein]]
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[[Category: Structural genomic]]
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[[Category: Structural genomics consortium]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 1 21:50:07 2008''
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Current revision

Structure of the regulator of G-protein signaling domain of RGS7

PDB ID 2a72

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