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3epv

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(New page: '''Unreleased structure''' The entry 3epv is ON HOLD Authors: Pompidor, Guillaume, Maillard, Antoine, Girard, Eric, Gambarelli, Serge, Kahn, Richard, Covès, Jacques Description:...)
Current revision (09:13, 23 February 2022) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 3epv is ON HOLD
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==X-ray Structure of the Metal-sensor CnrX in both the Apo- and Copper-bound Forms==
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<StructureSection load='3epv' size='340' side='right'caption='[[3epv]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3epv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Cupmc Cupmc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EPV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EPV FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">cnrR, cnrX, RMe0087, Rmet_6206 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=266264 CUPMC])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3epv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3epv OCA], [https://pdbe.org/3epv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3epv RCSB], [https://www.ebi.ac.uk/pdbsum/3epv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3epv ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/CNRR_RALME CNRR_RALME]] CnrH alone is able to activate cnr expression, while both CnrY and CrnR (CnrX) are needed for nickel induction of CnrH (PubMed:10671463). Has been suggested (PubMed:10671464) to bind nickel.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ep/3epv_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3epv ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Both the X-ray structures of the apo- and the copper-bound forms of the metal-sensor domain (residues 31-148) of CnrX from Cupriavidus metallidurans CH34 were obtained at 1.74A resolution from a selenomethionine derivative. This four-helix hooked-hairpin is the first structure of a metal-sensor in an ECF-type signaling pathway. The copper ion is bound in a type 2-like center with a 3N1O coordination in the equatorial plane and shows an unprecedented remote fifth axial ligand with Met93 contributing a weak S-Cu bond. The signal onset cannot be explained by conformational changes associated with CnrX metallation.
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Authors: Pompidor, Guillaume, Maillard, Antoine, Girard, Eric, Gambarelli, Serge, Kahn, Richard, Covès, Jacques
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X-ray structure of the metal-sensor CnrX in both the apo- and copper-bound forms.,Pompidor G, Maillard AP, Girard E, Gambarelli S, Kahn R, Coves J FEBS Lett. 2008 Nov 26;582(28):3954-8. Epub 2008 Nov 4. PMID:18992246<ref>PMID:18992246</ref>
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Description: X-ray Structure of the Metal-sensor CnrX in both the Apo-and Copper-bound Forms
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 8 09:21:20 2008''
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<div class="pdbe-citations 3epv" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Cupmc]]
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[[Category: Large Structures]]
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[[Category: Coves, J]]
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[[Category: Gambarelli, S]]
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[[Category: Girard, E]]
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[[Category: Kahn, R]]
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[[Category: Maillard, A P]]
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[[Category: Pompidor, G]]
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[[Category: All alpha helix]]
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[[Category: Cobalt]]
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[[Category: Metal binding protein]]
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[[Category: Nickel]]

Current revision

X-ray Structure of the Metal-sensor CnrX in both the Apo- and Copper-bound Forms

PDB ID 3epv

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