3efx

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{{Seed}}
 
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[[Image:3efx.png|left|200px]]
 
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==Novel binding site identified in a hybrid between cholera toxin and heat-labile enterotoxin, 1.9A crystal structure reveals the details==
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The line below this paragraph, containing "STRUCTURE_3efx", creates the "Structure Box" on the page.
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<StructureSection load='3efx' size='340' side='right'caption='[[3efx]], [[Resolution|resolution]] 1.94&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3efx]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2nzg 2nzg] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1tl0 1tl0]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EFX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EFX FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.94&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>
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{{STRUCTURE_3efx| PDB=3efx | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3efx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3efx OCA], [https://pdbe.org/3efx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3efx RCSB], [https://www.ebi.ac.uk/pdbsum/3efx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3efx ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ELBH_ECOLX ELBH_ECOLX] The biological activity of the toxin is produced by the A chain, which activates intracellular adenyl cyclase.[https://www.uniprot.org/uniprot/CHTB_VIBCH CHTB_VIBCH] The B subunit pentameric ring directs the A subunit to its target by binding to the GM1 gangliosides present on the surface of the intestinal epithelial cells. It can bind five GM1 gangliosides. It has no toxic activity by itself.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ef/3efx_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3efx ConSurf].
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<div style="clear:both"></div>
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===Novel binding site identified in a hybrid between cholera toxin and heat-labile enterotoxin, 1.9A crystal structure reveals the details===
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==See Also==
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*[[Cholera toxin 3D structures|Cholera toxin 3D structures]]
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*[[User:David Solfiell/sandbox 1|User:David Solfiell/sandbox 1]]
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__TOC__
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The line below this paragraph, {{ABSTRACT_PUBMED_15341730}}, adds the Publication Abstract to the page
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 15341730 is the PubMed ID number.
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[[Category: Large Structures]]
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[[Category: Vibrio cholerae]]
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{{ABSTRACT_PUBMED_15341730}}
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[[Category: Angstrom J]]
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[[Category: Holmner A]]
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==About this Structure==
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[[Category: Krengel U]]
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3EFX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Vibrio_cholerae,_escherichia_coli Vibrio cholerae, escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EFX OCA].
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[[Category: Lebens M]]
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[[Category: Okvist M]]
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==Reference==
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[[Category: Teneberg S]]
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Novel binding site identified in a hybrid between cholera toxin and heat-labile enterotoxin: 1.9 A crystal structure reveals the details., Holmner A, Lebens M, Teneberg S, Angstrom J, Okvist M, Krengel U, Structure. 2004 Sep;12(9):1655-67. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15341730 15341730]
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[[Category: Single protein]]
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[[Category: Vibrio cholerae, escherichia coli]]
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[[Category: Angstrom, J.]]
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[[Category: Holmner, A.]]
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[[Category: Krengel, U.]]
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[[Category: Lebens, M.]]
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[[Category: Okvist, M.]]
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[[Category: Teneberg, S.]]
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[[Category: Blood group antigen]]
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[[Category: Cholera toxin]]
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[[Category: Heat-labile enterotoxin]]
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[[Category: Protein-carbohydrate complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 8 20:11:13 2008''
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Current revision

Novel binding site identified in a hybrid between cholera toxin and heat-labile enterotoxin, 1.9A crystal structure reveals the details

PDB ID 3efx

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