3ddt

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{{Seed}}
 
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[[Image:3ddt.png|left|200px]]
 
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==Crystal structure of the B2 box from MuRF1 in dimeric state==
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The line below this paragraph, containing "STRUCTURE_3ddt", creates the "Structure Box" on the page.
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<StructureSection load='3ddt' size='340' side='right'caption='[[3ddt]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3ddt]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DDT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DDT FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3ddt| PDB=3ddt | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ddt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ddt OCA], [https://pdbe.org/3ddt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ddt RCSB], [https://www.ebi.ac.uk/pdbsum/3ddt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ddt ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TRI63_HUMAN TRI63_HUMAN] E3 ubiquitin ligase. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.<ref>PMID:11927605</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dd/3ddt_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ddt ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of the B2 box from MuRF1 in dimeric state===
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==See Also==
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*[[Mur ligase|Mur ligase]]
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*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]
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== References ==
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The line below this paragraph, {{ABSTRACT_PUBMED_18795805}}, adds the Publication Abstract to the page
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<references/>
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(as it appears on PubMed at http://www.pubmed.gov), where 18795805 is the PubMed ID number.
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__TOC__
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</StructureSection>
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{{ABSTRACT_PUBMED_18795805}}
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==About this Structure==
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3DDT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DDT OCA].
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==Reference==
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Structural analysis of B-Box 2 from MuRF1: identification of a novel self-association pattern in a RING-like fold., Mrosek M, Meier S, Ucurum-Fotiadis Z, von Castelmur E, Hedbom E, Lustig A, Grzesiek S, Labeit D, Labeit S, Mayans O, Biochemistry. 2008 Oct 7;47(40):10722-30. Epub 2008 Sep 17. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18795805 18795805]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Mayans, O.]]
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[[Category: Mayans O]]
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[[Category: Mrosek, M.]]
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[[Category: Mrosek M]]
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[[Category: Coiled coil]]
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[[Category: Cytoplasm]]
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[[Category: Ligase]]
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[[Category: Metal-binding]]
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[[Category: Muscle protein]]
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[[Category: Nucleus]]
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[[Category: Polymorphism]]
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[[Category: Ring-like fold]]
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[[Category: Ubl conjugation pathway]]
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[[Category: Zinc]]
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[[Category: Zinc-binding motif]]
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[[Category: Zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 15 12:38:37 2008''
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Current revision

Crystal structure of the B2 box from MuRF1 in dimeric state

PDB ID 3ddt

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OCA

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