3d9c

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{{Seed}}
 
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[[Image:3d9c.png|left|200px]]
 
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==Crystal Structure PTP1B complex with aryl Seleninic acid==
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The line below this paragraph, containing "STRUCTURE_3d9c", creates the "Structure Box" on the page.
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<StructureSection load='3d9c' size='340' side='right'caption='[[3d9c]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3d9c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D9C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3D9C FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZYZ:(4-{(2S)-2-[(TERT-BUTOXYCARBONYL)AMINO]-3-METHOXY-3-OXOPROPYL}PHENYL)METHANESELENINIC+ACID'>ZYZ</scene></td></tr>
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{{STRUCTURE_3d9c| PDB=3d9c | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3d9c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d9c OCA], [https://pdbe.org/3d9c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3d9c RCSB], [https://www.ebi.ac.uk/pdbsum/3d9c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3d9c ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d9/3d9c_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3d9c ConSurf].
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<div style="clear:both"></div>
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===Crystal Structure PTP1B complex with aryl Seleninic acid===
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==See Also==
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*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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3D9C is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D9C OCA].
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__TOC__
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</StructureSection>
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==Reference==
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Seleninate in place of phosphate: irreversible inhibition of protein tyrosine phosphatases., Abdo M, Liu S, Zhou B, Walls CD, Wu L, Knapp S, Zhang ZY, J Am Chem Soc. 2008 Oct 8;130(40):13196-7. Epub 2008 Sep 10. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18781746 18781746]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein-tyrosine-phosphatase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Abdo M]]
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[[Category: Abdo, M.]]
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[[Category: Knapp S]]
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[[Category: Knapp, S.]]
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[[Category: Liu S]]
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[[Category: Liu, S.]]
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[[Category: Walls CD]]
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[[Category: Walls, C D.]]
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[[Category: Zhang Z-Y]]
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[[Category: Zhang, Z Y.]]
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[[Category: Zhou B]]
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[[Category: Zhou, B.]]
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[[Category: Acetylation]]
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[[Category: Covalent bond]]
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[[Category: Crystal structure]]
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[[Category: Endoplasmic reticulum]]
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[[Category: Hydrolase]]
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[[Category: Inhibitor]]
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[[Category: Membrane]]
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[[Category: Oxidation]]
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[[Category: Phosphoprotein]]
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[[Category: Polymorphism]]
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[[Category: Protein phosphatase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 15 12:47:50 2008''
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Current revision

Crystal Structure PTP1B complex with aryl Seleninic acid

PDB ID 3d9c

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