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1iba

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(New page: 200px<br /> <applet load="1iba" size="450" color="white" frame="true" align="right" spinBox="true" caption="1iba" /> '''GLUCOSE PERMEASE (DOMAIN IIB), NMR, 11 STRU...)
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[[Image:1iba.gif|left|200px]]<br />
 
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<applet load="1iba" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1iba" />
 
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'''GLUCOSE PERMEASE (DOMAIN IIB), NMR, 11 STRUCTURES'''<br />
 
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==Overview==
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==GLUCOSE PERMEASE (DOMAIN IIB), NMR, 11 STRUCTURES==
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The structure of the IIBGlc domain of the Escherichia coli transporter for, glucose was determined by multidimensional heteronuclear NMR. The glucose, transporter (IICBGlc) belongs to the bacterial phosphotransferase system., It mediates uptake with concomittant phosphorylation of glucose. The, N-terminal IICGlc domain spans the membrane, the C-terminal IIBGlc domain, (residues 386-477) contains the phosphorylation site, Cys421. The, structure of the subclonal IIB domain was determined based on 927, conformational constraints, including 744 NOE derived upper bounds, 43, constraints of ranges of dihedral angles based on measurements of vicinal, coupling constants, and 70 upper and lower bound constraints associated, with 35 hydrogen bonds. The distance geometry interpretation of the NMR, ... [[http://ispc.weizmann.ac.il/pmbin/getpm?8784182 (full description)]]
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<StructureSection load='1iba' size='340' side='right'caption='[[1iba]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1iba]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IBA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IBA FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1iba FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iba OCA], [https://pdbe.org/1iba PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1iba RCSB], [https://www.ebi.ac.uk/pdbsum/1iba PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1iba ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PTGCB_ECOLI PTGCB_ECOLI] The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in glucose transport. This enzyme is also a chemoreceptor monitoring the environment for changes in sugar concentration.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ib/1iba_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1iba ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1IBA is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.69 2.7.1.69]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1IBA OCA]].
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*[[Lysozyme 3D structures|Lysozyme 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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Solution structure of the IIB domain of the glucose transporter of Escherichia coli., Eberstadt M, Grdadolnik SG, Gemmecker G, Kessler H, Buhr A, Erni B, Biochemistry. 1996 Sep 3;35(35):11286-92. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8784182 8784182]
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Buhr, A.]]
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[[Category: Buhr A]]
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[[Category: Eberstadt, M.]]
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[[Category: Eberstadt M]]
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[[Category: Erni, B.]]
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[[Category: Erni B]]
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[[Category: Gemmecker, G.]]
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[[Category: Gemmecker G]]
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[[Category: Grdadolnik, S.G.]]
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[[Category: Grdadolnik SG]]
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[[Category: Kessler, H.]]
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[[Category: Kessler H]]
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[[Category: inner membrane]]
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[[Category: phosphorylation]]
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[[Category: phosphotransferase system]]
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[[Category: sugar transport]]
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[[Category: transferase]]
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[[Category: transmembrane]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 21:06:52 2007''
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Current revision

GLUCOSE PERMEASE (DOMAIN IIB), NMR, 11 STRUCTURES

PDB ID 1iba

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