2rj2

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{{Seed}}
 
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[[Image:2rj2.jpg|left|200px]]
 
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==Crystal Structure of the Sugar Recognizing SCF Ubiquitin Ligase at 1.7 Resolution==
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The line below this paragraph, containing "STRUCTURE_2rj2", creates the "Structure Box" on the page.
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<StructureSection load='2rj2' size='340' side='right'caption='[[2rj2]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2rj2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RJ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RJ2 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
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{{STRUCTURE_2rj2| PDB=2rj2 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rj2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rj2 OCA], [https://pdbe.org/2rj2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rj2 RCSB], [https://www.ebi.ac.uk/pdbsum/2rj2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rj2 ProSAT]</span></td></tr>
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</table>
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===Crystal Structure of the Sugar Recognizing SCF Ubiquitin Ligase at 1.7 Resolution===
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== Function ==
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[https://www.uniprot.org/uniprot/FBX2_MOUSE FBX2_MOUSE] Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type.<ref>PMID:12140560</ref> <ref>PMID:15723043</ref> <ref>PMID:17720138</ref> <ref>PMID:17215248</ref> <ref>PMID:14990996</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_14990996}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 14990996 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rj/2rj2_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_14990996}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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2RJ2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RJ2 OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rj2 ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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Structural basis of sugar-recognizing ubiquitin ligase., Mizushima T, Hirao T, Yoshida Y, Lee SJ, Chiba T, Iwai K, Yamaguchi Y, Kato K, Tsukihara T, Tanaka K, Nat Struct Mol Biol. 2004 Apr;11(4):365-70. Epub 2004 Feb 29. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14990996 14990996]
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Single protein]]
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[[Category: Mizushima T]]
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[[Category: Ubiquitin--protein ligase]]
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[[Category: Tanaka K]]
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[[Category: Mizushima, T.]]
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[[Category: Vaijayanthimala S]]
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[[Category: Tanaka, K.]]
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[[Category: Velmurugan D]]
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[[Category: Vaijayanthimala, S.]]
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[[Category: Yamane T]]
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[[Category: Velmurugan, D.]]
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[[Category: Yoshida Y]]
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[[Category: Yamane, T.]]
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[[Category: Yoshida, Y.]]
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[[Category: Lectin]]
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[[Category: Scf]]
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[[Category: Ubiquitin]]
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[[Category: Ubiquitin ligase]]
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[[Category: Ubl conjugation pathway]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 15 14:11:10 2008''
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Current revision

Crystal Structure of the Sugar Recognizing SCF Ubiquitin Ligase at 1.7 Resolution

PDB ID 2rj2

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