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1tdk

From Proteopedia

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(New page: 200px<br /><applet load="1tdk" size="450" color="white" frame="true" align="right" spinBox="true" caption="1tdk, resolution 2.70&Aring;" /> '''L-amino acid oxidase...)
Current revision (07:27, 25 October 2023) (edit) (undo)
 
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[[Image:1tdk.gif|left|200px]]<br /><applet load="1tdk" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1tdk, resolution 2.70&Aring;" />
 
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'''L-amino acid oxidase from Agkistrodon halys in complex with suicide substrate L-vinylglycine'''<br />
 
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==About this Structure==
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==L-amino acid oxidase from Agkistrodon halys in complex with suicide substrate L-vinylglycine==
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1TDK is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Gloydius_halys Gloydius halys] with NAG, NDG, FAD and LVG as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/L-amino-acid_oxidase L-amino-acid oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.2 1.4.3.2] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1TDK OCA].
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<StructureSection load='1tdk' size='340' side='right'caption='[[1tdk]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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[[Category: Gloydius halys]]
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== Structural highlights ==
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[[Category: L-amino-acid oxidase]]
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<table><tr><td colspan='2'>[[1tdk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gloydius_halys Gloydius halys]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TDK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TDK FirstGlance]. <br>
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[[Category: Single protein]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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[[Category: Niu, L.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=LVG:L-VINYLGLYCINE'>LVG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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[[Category: Teng, M.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tdk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tdk OCA], [https://pdbe.org/1tdk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tdk RCSB], [https://www.ebi.ac.uk/pdbsum/1tdk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tdk ProSAT]</span></td></tr>
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[[Category: Zhang, H.]]
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</table>
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[[Category: FAD]]
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== Function ==
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[[Category: LVG]]
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[https://www.uniprot.org/uniprot/OXLA_GLOHA OXLA_GLOHA] Catalyzes an oxidative deamination of predominantly hydrophobic and aromatic L-amino acids, thus producing hydrogen peroxide that may contribute to the diverse toxic effects of this enzyme. Exhibits diverse biological activities, such as hemorrhage, hemolysis, edema, antibacterial and antiparasitic activities, as well as regulation of platelet aggregation. Its effect on platelets is controversial, since it either induces aggregation or inhibits agonist-induced aggregation. These different effects are probably due to different experimental conditions (By similarity). This protein induces apoptosis of cultured HeLa cells.<ref>PMID:15103157</ref>
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[[Category: NAG]]
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== Evolutionary Conservation ==
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[[Category: NDG]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: complex structure with suicide substrate]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/td/1tdk_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tdk ConSurf].
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<div style="clear:both"></div>
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 03:10:54 2007''
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==See Also==
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*[[Amino acid oxidase 3D structures|Amino acid oxidase 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Gloydius halys]]
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[[Category: Large Structures]]
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[[Category: Niu L]]
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[[Category: Teng M]]
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[[Category: Zhang H]]

Current revision

L-amino acid oxidase from Agkistrodon halys in complex with suicide substrate L-vinylglycine

PDB ID 1tdk

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