1tig

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(New page: 200px<br /><applet load="1tig" size="450" color="white" frame="true" align="right" spinBox="true" caption="1tig, resolution 2.0&Aring;" /> '''TRANSLATION INITIATIO...)
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[[Image:1tig.gif|left|200px]]<br /><applet load="1tig" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1tig, resolution 2.0&Aring;" />
 
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'''TRANSLATION INITIATION FACTOR 3 C-TERMINAL DOMAIN'''<br />
 
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==Overview==
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==TRANSLATION INITIATION FACTOR 3 C-TERMINAL DOMAIN==
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The structures of the two domains of translational initiation factor IF3, from Bacillus stearothermophilus have been solved by X-ray crystallography, using single wavelength anomalous scattering and multiwavelength anomalous, diffraction. Each of the two domains has an alpha/beta topology, with an, exposed beta-sheet that is reminiscent of several ribosomal and other RNA, binding proteins. An alpha-helix that protrudes out from the body of the, N-terminal domain towards the C-terminal domain suggests that IF3 consists, of two RNA binding domains connected by an alpha-helix and that it may, bridge two regions of the ribosome. This represents the first high, resolution structural information on a translational initiation factor.
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<StructureSection load='1tig' size='340' side='right'caption='[[1tig]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1tig]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TIG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TIG FirstGlance]. <br>
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1TIG is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1TIG OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tig FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tig OCA], [https://pdbe.org/1tig PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tig RCSB], [https://www.ebi.ac.uk/pdbsum/1tig PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tig ProSAT]</span></td></tr>
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==Reference==
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</table>
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X-ray crystallography shows that translational initiation factor IF3 consists of two compact alpha/beta domains linked by an alpha-helix., Biou V, Shu F, Ramakrishnan V, EMBO J. 1995 Aug 15;14(16):4056-64. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7664745 7664745]
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== Function ==
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[https://www.uniprot.org/uniprot/IF3_GEOSE IF3_GEOSE] IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ti/1tig_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tig ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Geobacillus stearothermophilus]]
[[Category: Geobacillus stearothermophilus]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Biou, V.]]
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[[Category: Biou V]]
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[[Category: Ramakrishnan, V.]]
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[[Category: Ramakrishnan V]]
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[[Category: Shu, F.]]
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[[Category: Shu F]]
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[[Category: if3 c-terminal domain]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 03:17:38 2007''
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TRANSLATION INITIATION FACTOR 3 C-TERMINAL DOMAIN

PDB ID 1tig

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