2w1z
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 2w1z is ON HOLD until Paper Publication Authors: Labesse, G., Gelin, M., Bessin, Y., Lebrun, M., Arold, S., Dubremetz, J.-F. Description: ROP2 from...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==ROP2 from Toxoplasma gondii: A virulence factor with a protein- kinase fold and no enzymatic activity.== | |
| + | <StructureSection load='2w1z' size='340' side='right'caption='[[2w1z]], [[Resolution|resolution]] 1.97Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2w1z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Toxoplasma_gondii_RH Toxoplasma gondii RH]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W1Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W1Z FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.97Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w1z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w1z OCA], [https://pdbe.org/2w1z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w1z RCSB], [https://www.ebi.ac.uk/pdbsum/2w1z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w1z ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/Q27007_TOXGO Q27007_TOXGO] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The ROP2 protein and its paralogs are important virulence factors secreted into the host cell by the parasite Toxoplasma gondii. Here we describe the crystal structure of a large and soluble domain of mature ROP2, representative of the ROP2-like protein family. This is a structure of a protein-kinase fold that is devoid of catalytic residues and does not bind ATP. Various structural extensions constitute a signature of this protein family and act to maintain the protein kinase in an open conformation. Our ROP2 structure rules out a previous structural model of attachment of ROP2-like proteins to the parasitophorous vacuole membrane. We propose an alternative mode of membrane attachment implicating basic and amphiphatic helices present in the flexible N terminus of ROP2. | ||
| - | + | ROP2 from Toxoplasma gondii: a virulence factor with a protein-kinase fold and no enzymatic activity.,Labesse G, Gelin M, Bessin Y, Lebrun M, Papoin J, Cerdan R, Arold ST, Dubremetz JF Structure. 2009 Jan 14;17(1):139-46. PMID:19141290<ref>PMID:19141290</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 2w1z" style="background-color:#fffaf0;"></div> | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Toxoplasma gondii RH]] | ||
| + | [[Category: Arold ST]] | ||
| + | [[Category: Bessin Y]] | ||
| + | [[Category: Dubremetz J-F]] | ||
| + | [[Category: Gelin M]] | ||
| + | [[Category: Labesse G]] | ||
| + | [[Category: Lebrun M]] | ||
Current revision
ROP2 from Toxoplasma gondii: A virulence factor with a protein- kinase fold and no enzymatic activity.
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