2zpp

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{{Seed}}
 
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[[Image:2zpp.jpg|left|200px]]
 
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==Neutron crystal structure of cubic insulin at pD9==
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The line below this paragraph, containing "STRUCTURE_2zpp", creates the "Structure Box" on the page.
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<StructureSection load='2zpp' size='340' side='right'caption='[[2zpp]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2zpp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZPP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZPP FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Neutron Diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DOD:DEUTERATED+WATER'>DOD</scene></td></tr>
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{{STRUCTURE_2zpp| PDB=2zpp | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zpp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zpp OCA], [https://pdbe.org/2zpp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zpp RCSB], [https://www.ebi.ac.uk/pdbsum/2zpp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zpp ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/INS_PIG INS_PIG] Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zp/2zpp_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zpp ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Insulin is stored in pancreatic beta-cell as hexameric form with Zn2+ ions, while the hormonally active form is monomer. The hexamer requires the coordination of Zn2+ ions to the HisB10. In order to reveal the mechanism of the hexamerization of insulin, we investigated the Zn2+ free insulin at pD6.6 and pD9 by neutron crystallographic analyses. HisB10 is doubly protonated not only at pD6.6 but also at pD9, indicating an abnormal pK(a) of this histidine. It is suggested that HisB10 acts on a strong cation capture and contributes to the high stability of the hexameric form in pancreas.
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===Neutron crystal structure of cubic insulin at pD9===
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An abnormal pK(a) value of internal histidine of the insulin molecule revealed by neutron crystallographic analysis.,Ishikawa T, Chatake T, Morimoto Y, Maeda M, Kurihara K, Tanaka I, Niimura N Biochem Biophys Res Commun. 2008 Nov 7;376(1):32-5. Epub 2008 Aug 24. PMID:18725203<ref>PMID:18725203</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2zpp" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_18725203}}, adds the Publication Abstract to the page
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*[[Insulin 3D Structures|Insulin 3D Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 18725203 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_18725203}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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2ZPP is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZPP OCA].
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==Reference==
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An abnormal pK(a) value of internal histidine of the insulin molecule revealed by neutron crystallographic analysis., Ishikawa T, Chatake T, Morimoto Y, Maeda M, Kurihara K, Tanaka I, Niimura N, Biochem Biophys Res Commun. 2008 Nov 7;376(1):32-5. Epub 2008 Aug 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18725203 18725203]
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[[Category: Protein complex]]
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[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
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[[Category: Ishikawa, T.]]
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[[Category: Ishikawa T]]
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[[Category: Niimura, N.]]
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[[Category: Niimura N]]
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[[Category: Tanaka, I.]]
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[[Category: Tanaka I]]
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[[Category: Carbohydrate metabolism]]
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[[Category: Cleavage on pair of basic residue]]
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[[Category: Cubic]]
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[[Category: Glucose metabolism]]
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[[Category: Hormone]]
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[[Category: Neutron diffraction]]
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[[Category: Porcine insulin]]
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[[Category: Secreted]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 29 10:52:18 2008''
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Current revision

Neutron crystal structure of cubic insulin at pD9

PDB ID 2zpp

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OCA

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