3dyu

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{{Seed}}
 
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[[Image:3dyu.png|left|200px]]
 
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==Crystal structure of Snx9PX-BAR (230-595), H32==
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The line below this paragraph, containing "STRUCTURE_3dyu", creates the "Structure Box" on the page.
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<StructureSection load='3dyu' size='340' side='right'caption='[[3dyu]], [[Resolution|resolution]] 4.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3dyu]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DYU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DYU FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dyu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dyu OCA], [https://pdbe.org/3dyu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dyu RCSB], [https://www.ebi.ac.uk/pdbsum/3dyu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dyu ProSAT]</span></td></tr>
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{{STRUCTURE_3dyu| PDB=3dyu | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SNX9_HUMAN SNX9_HUMAN] May be involved in several stages of intracellular trafficking. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F-actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate.<ref>PMID:11799118</ref> <ref>PMID:12952949</ref> <ref>PMID:15703209</ref> <ref>PMID:17609109</ref> <ref>PMID:18388313</ref> <ref>PMID:20427313</ref> <ref>PMID:21048941</ref> <ref>PMID:17948057</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dy/3dyu_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dyu ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Endophilin and Sorting Nexin 9 (Snx9) play key roles in endocytosis by membrane curvature sensing and remodeling via their Bin/Amphiphysin/Rvs (BAR) domains. BAR and the related F-BAR domains form dimeric, crescent-shaped units that occur N- or C-terminally to other lipid-binding, adaptor, or catalytic modules. In crystal structures, the PX-BAR unit of Snx9 (Snx9(PX-BAR)) adopts an overall compact, moderately curved conformation. SAXS-based solution studies revealed an alternative, more curved state of Snx9(PX-BAR) in which the PX domains are flexibly connected to the BAR domains, providing a model for how Snx9 exhibits lipid-dependent curvature preferences. In contrast, Endophilin appears to be rigid in solution, and the SH3 domains are located at the distal tips of a BAR domain dimer with fixed curvature. We also observed tip-to-tip interactions between the BAR domains in a trigonal crystal form of Snx9(PX-BAR) reminiscent of functionally important interactions described for F-BAR domains.
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===Crystal structure of Snx9PX-BAR (230-595), H32===
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Structure and plasticity of Endophilin and Sorting Nexin 9.,Wang Q, Kaan HY, Hooda RN, Goh SL, Sondermann H Structure. 2008 Oct 8;16(10):1574-87. PMID:18940612<ref>PMID:18940612</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3dyu" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_18940612}}, adds the Publication Abstract to the page
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*[[Sorting nexin 3D structures|Sorting nexin 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 18940612 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_18940612}}
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__TOC__
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</StructureSection>
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==About this Structure==
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3DYU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DYU OCA].
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==Reference==
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Structure and plasticity of Endophilin and Sorting Nexin 9., Wang Q, Kaan HY, Hooda RN, Goh SL, Sondermann H, Structure. 2008 Oct 8;16(10):1574-87. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18940612 18940612]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Kaan, H Y.K.]]
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[[Category: Kaan HYK]]
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[[Category: Sondermann, H.]]
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[[Category: Sondermann H]]
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[[Category: Wang, Q.]]
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[[Category: Wang Q]]
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[[Category: 3-helix-bundle]]
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[[Category: Bar domain]]
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[[Category: Phosphoprotein]]
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[[Category: Protein transport]]
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[[Category: Px domain]]
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[[Category: Sh3 domain]]
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[[Category: Transport]]
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[[Category: Transport protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 5 10:37:12 2008''
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Current revision

Crystal structure of Snx9PX-BAR (230-595), H32

PDB ID 3dyu

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