2jw1

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{{Seed}}
 
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[[Image:2jw1.png|left|200px]]
 
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==Structural characterization of the type III pilotin-secretin interaction in Shigella flexneri by NMR spectroscopy==
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The line below this paragraph, containing "STRUCTURE_2jw1", creates the "Structure Box" on the page.
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<StructureSection load='2jw1' size='340' side='right'caption='[[2jw1]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2jw1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Shigella_flexneri Shigella flexneri] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JW1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JW1 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 15 models</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
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{{STRUCTURE_2jw1| PDB=2jw1 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jw1 OCA], [https://pdbe.org/2jw1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jw1 RCSB], [https://www.ebi.ac.uk/pdbsum/2jw1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jw1 ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Assembly of the type-III secretion apparatus, which translocates proteins through both membranes of Gram-negative bacterial pathogens into host cells, requires the formation of an integral outer-membrane secretin ring. Typically, a small lipidated pilot protein is necessary for the stabilization and localization of this ring. Using NMR spectroscopy, we demonstrate that the C-terminal residues 553-570 of the Shigella flexneri secretin MxiD encompass the minimal binding domain for its cognate pilot MxiM. Although unstructured in isolation, upon complex formation with MxiM, these residues fold into an amphipathic turn-helix motif that caps the elongated hydrophobic cavity of the cracked beta-barrel pilot. Along with a rearrangement of core aromatic residues, this prevents the binding of lipids within the cavity. The mutually exclusive association of lipids and MxiD with MxiM establishes a framework for understanding the role of a pilot in the outer-membrane insertion and multimerization of the secretin ring.
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===Structural characterization of the type III pilotin-secretin interaction in Shigella flexneri by NMR spectroscopy===
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Structural characterization of the type-III pilot-secretin complex from Shigella flexneri.,Okon M, Moraes TF, Lario PI, Creagh AL, Haynes CA, Strynadka NC, McIntosh LP Structure. 2008 Oct 8;16(10):1544-54. PMID:18940609<ref>PMID:18940609</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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The line below this paragraph, {{ABSTRACT_PUBMED_18940609}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2jw1" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 18940609 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_18940609}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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2JW1 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Shigella_flexneri Shigella flexneri]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JW1 OCA].
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==Reference==
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Structural characterization of the type-III pilot-secretin complex from Shigella flexneri., Okon M, Moraes TF, Lario PI, Creagh AL, Haynes CA, Strynadka NC, McIntosh LP, Structure. 2008 Oct 8;16(10):1544-54. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18940609 18940609]
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[[Category: Protein complex]]
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[[Category: Shigella flexneri]]
[[Category: Shigella flexneri]]
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[[Category: Creagh, L.]]
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[[Category: Synthetic construct]]
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[[Category: Jung, Y M.T.]]
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[[Category: Creagh L]]
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[[Category: Lario, P I.]]
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[[Category: Jung YMT]]
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[[Category: Maurelli, A T.]]
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[[Category: Lario PI]]
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[[Category: McIntosh, L P.]]
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[[Category: Maurelli AT]]
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[[Category: Okon, M S.]]
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[[Category: McIntosh LP]]
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[[Category: Strynadka, N C.J.]]
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[[Category: Okon MS]]
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[[Category: Lipoprotein]]
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[[Category: Strynadka NCJ]]
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[[Category: Membrane]]
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[[Category: Membrane protein]]
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[[Category: Outer membrane]]
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[[Category: Palmitate]]
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[[Category: Plasmid]]
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[[Category: Protein transport]]
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[[Category: Protein-protein interaction]]
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[[Category: Transport]]
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[[Category: Virulence]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 5 10:45:21 2008''
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Current revision

Structural characterization of the type III pilotin-secretin interaction in Shigella flexneri by NMR spectroscopy

PDB ID 2jw1

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