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3f2k

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(New page: '''Unreleased structure''' The entry 3f2k is ON HOLD Authors: Amaya, M.F., Dombrovski, L., Ni, S., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Botchkarev, A., Min, J., Pl...)
Current revision (06:40, 6 September 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 3f2k is ON HOLD
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==Structure of the transposase domain of human Histone-lysine N-methyltransferase SETMAR==
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<StructureSection load='3f2k' size='340' side='right'caption='[[3f2k]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3f2k]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F2K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3F2K FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3f2k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f2k OCA], [https://pdbe.org/3f2k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3f2k RCSB], [https://www.ebi.ac.uk/pdbsum/3f2k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3f2k ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SETMR_HUMAN SETMR_HUMAN] Histone methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3, 2 specific tags for epigenetic transcriptional activation. Specifically mediates dimethylation of H3 'Lys-36'. Has sequence-specific DNA-binding activity and recognizes the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element. Has DNA nicking activity. Has in vivo end joining activity and may mediate genomic integration of foreign DNA.<ref>PMID:16332963</ref> <ref>PMID:16672366</ref> <ref>PMID:17877369</ref> <ref>PMID:17403897</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f2/3f2k_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3f2k ConSurf].
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<div style="clear:both"></div>
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Authors: Amaya, M.F., Dombrovski, L., Ni, S., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Botchkarev, A., Min, J., Plotnikov, A.N., Wu, H., Structural Genomics Consortium (SGC)
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==See Also==
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*[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]]
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Description: Structure of the transposase domain of human Histone-lysine N-methyltransferase SETMAR
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== References ==
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<references/>
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 5 11:45:04 2008''
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Amaya MF]]
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[[Category: Arrowsmith CH]]
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[[Category: Botchkarev A]]
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[[Category: Bountra C]]
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[[Category: Dombrovski L]]
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[[Category: Edwards AM]]
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[[Category: Min J]]
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[[Category: Ni S]]
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[[Category: Plotnikov AN]]
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[[Category: Weigelt J]]
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[[Category: Wu H]]

Current revision

Structure of the transposase domain of human Histone-lysine N-methyltransferase SETMAR

PDB ID 3f2k

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