3cuq

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{{Seed}}
 
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[[Image:3cuq.jpg|left|200px]]
 
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==Integrated structural and functional model of the human ESCRT-II complex==
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The line below this paragraph, containing "STRUCTURE_3cuq", creates the "Structure Box" on the page.
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<StructureSection load='3cuq' size='340' side='right'caption='[[3cuq]], [[Resolution|resolution]] 2.61&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3cuq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CUQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CUQ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.61&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cuq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cuq OCA], [https://pdbe.org/3cuq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cuq RCSB], [https://www.ebi.ac.uk/pdbsum/3cuq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cuq ProSAT]</span></td></tr>
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{{STRUCTURE_3cuq| PDB=3cuq | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SNF8_HUMAN SNF8_HUMAN] Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL. Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization. It is also required for the degradation of CXCR4.<ref>PMID:17959629</ref> <ref>PMID:17714434</ref> <ref>PMID:18031739</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cu/3cuq_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cuq ConSurf].
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<div style="clear:both"></div>
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===Integrated structural and functional model of the human ESCRT-II complex===
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==See Also==
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*[[Vacuolar protein sorting-associated protein 3D structures|Vacuolar protein sorting-associated protein 3D structures]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 18539118 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_18539118}}
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==About this Structure==
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3CUQ is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CUQ OCA].
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==Reference==
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Integrated structural model and membrane targeting mechanism of the human ESCRT-II complex., Im YJ, Hurley JH, Dev Cell. 2008 Jun;14(6):902-13. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18539118 18539118]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Hurley, J H.]]
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[[Category: Hurley JH]]
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[[Category: Im, Y J.]]
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[[Category: Im YJ]]
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[[Category: Alternative splicing]]
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[[Category: Coiled coil]]
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[[Category: Cytoplasm]]
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[[Category: Endosome]]
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[[Category: Escrt]]
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[[Category: Lipid-binding]]
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[[Category: Mbv]]
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[[Category: Nucleus]]
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[[Category: Protein transport]]
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[[Category: Sorting]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Transport]]
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[[Category: Vp]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 5 12:42:48 2008''
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Current revision

Integrated structural and functional model of the human ESCRT-II complex

PDB ID 3cuq

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OCA

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