3dvm

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{{Seed}}
 
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[[Image:3dvm.jpg|left|200px]]
 
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==Crystal Structure of Ca2+/CaM-CaV2.1 IQ domain complex==
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The line below this paragraph, containing "STRUCTURE_3dvm", creates the "Structure Box" on the page.
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<StructureSection load='3dvm' size='340' side='right'caption='[[3dvm]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3dvm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DVM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DVM FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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{{STRUCTURE_3dvm| PDB=3dvm | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dvm OCA], [https://pdbe.org/3dvm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dvm RCSB], [https://www.ebi.ac.uk/pdbsum/3dvm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dvm ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/CALM1_HUMAN CALM1_HUMAN] The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of CPVT4. The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of LQT14.
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== Function ==
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[https://www.uniprot.org/uniprot/CALM1_HUMAN CALM1_HUMAN] Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696).<ref>PMID:16760425</ref> <ref>PMID:23893133</ref> <ref>PMID:26969752</ref> <ref>PMID:27165696</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dv/3dvm_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dvm ConSurf].
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<div style="clear:both"></div>
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===Crystal Structure of Ca2+/CaM-CaV2.1 IQ domain complex===
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==See Also==
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*[[Calmodulin 3D structures|Calmodulin 3D structures]]
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*[[Ion channels 3D structures|Ion channels 3D structures]]
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== References ==
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The line below this paragraph, {{ABSTRACT_PUBMED_18940602}}, adds the Publication Abstract to the page
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<references/>
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(as it appears on PubMed at http://www.pubmed.gov), where 18940602 is the PubMed ID number.
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__TOC__
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</StructureSection>
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{{ABSTRACT_PUBMED_18940602}}
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==About this Structure==
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3DVM is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DVM OCA].
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==Reference==
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Structures of CaV2 Ca2+/CaM-IQ domain complexes reveal binding modes that underlie calcium-dependent inactivation and facilitation., Kim EY, Rumpf CH, Fujiwara Y, Cooley ES, Van Petegem F, Minor DL Jr, Structure. 2008 Oct 8;16(10):1455-67. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18940602 18940602]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Large Structures]]
[[Category: Oryctolagus cuniculus]]
[[Category: Oryctolagus cuniculus]]
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[[Category: Protein complex]]
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[[Category: Cooley ES]]
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[[Category: Cooley, E S.]]
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[[Category: Fujiwara Y]]
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[[Category: Fujiwara, Y.]]
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[[Category: Kim EY]]
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[[Category: Kim, E Y.]]
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[[Category: Minor DL]]
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[[Category: Minor, D L.]]
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[[Category: Rumpf CH]]
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[[Category: Petegem, F Van.]]
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[[Category: Van Petegem F]]
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[[Category: Rumpf, C H.]]
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[[Category: Calcium channel]]
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[[Category: Calcium-dependent]]
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[[Category: Calmodulin]]
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[[Category: Facilitation]]
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[[Category: Inactivation]]
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[[Category: Iq domain]]
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[[Category: Membrane protein]]
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[[Category: Voltage-gated]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 5 12:47:26 2008''
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Current revision

Crystal Structure of Ca2+/CaM-CaV2.1 IQ domain complex

PDB ID 3dvm

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