3f0w

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: {{Seed}} 200px <!-- The line below this paragraph, containing "STRUCTURE_3f0w", creates the "Structure Box" on the page. You may change the PDB parameter (which se...)
Current revision (15:25, 1 November 2023) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:3f0w.jpg|left|200px]]
 
-
<!--
+
==Human NUMB-like protein, phosphotyrosine interaction domain==
-
The line below this paragraph, containing "STRUCTURE_3f0w", creates the "Structure Box" on the page.
+
<StructureSection load='3f0w' size='340' side='right'caption='[[3f0w]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3f0w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F0W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3F0W FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
{{STRUCTURE_3f0w| PDB=3f0w | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3f0w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f0w OCA], [https://pdbe.org/3f0w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3f0w RCSB], [https://www.ebi.ac.uk/pdbsum/3f0w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3f0w ProSAT]</span></td></tr>
-
 
+
</table>
-
===Human NUMB-like protein, phosphotyrosine interaction domain===
+
== Function ==
-
 
+
[https://www.uniprot.org/uniprot/NUMBL_HUMAN NUMBL_HUMAN] Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons.<ref>PMID:18299187</ref> <ref>PMID:20079715</ref>
-
 
+
== Evolutionary Conservation ==
-
==About this Structure==
+
[[Image:Consurf_key_small.gif|200px|right]]
-
3F0W is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F0W OCA].
+
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f0/3f0w_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3f0w ConSurf].
 +
<div style="clear:both"></div>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Andersson, J.]]
+
[[Category: Andersson J]]
-
[[Category: Arrowsmith, C H.]]
+
[[Category: Arrowsmith CH]]
-
[[Category: Berg, S Van Den.]]
+
[[Category: Berglund H]]
-
[[Category: Berglund, H.]]
+
[[Category: Bountra C]]
-
[[Category: Bountra, C.]]
+
[[Category: Collins R]]
-
[[Category: Busam, R D.]]
+
[[Category: D Busam R]]
-
[[Category: Collins, R.]]
+
[[Category: Dahlgren LG]]
-
[[Category: Dahlgren, L G.]]
+
[[Category: Edwards AM]]
-
[[Category: Edwards, A M.]]
+
[[Category: Flodin S]]
-
[[Category: Flodin, S.]]
+
[[Category: Flores A]]
-
[[Category: Flores, A.]]
+
[[Category: Graslund S]]
-
[[Category: Graslund, S.]]
+
[[Category: Hammarstrom M]]
-
[[Category: Hammarstrom, M.]]
+
[[Category: Johansson A]]
-
[[Category: Johansson, A.]]
+
[[Category: Johansson I]]
-
[[Category: Johansson, I.]]
+
[[Category: Karlberg T]]
-
[[Category: Karlberg, T.]]
+
[[Category: Kotenyova T]]
-
[[Category: Kotenyova, T.]]
+
[[Category: Lehtio L]]
-
[[Category: Lehtio, L.]]
+
[[Category: Moche M]]
-
[[Category: Moche, M.]]
+
[[Category: Nilsson ME]]
-
[[Category: Nilsson, M E.]]
+
[[Category: Nordlund P]]
-
[[Category: Nordlund, P.]]
+
[[Category: Nyman T]]
-
[[Category: Nyman, T.]]
+
[[Category: Persson C]]
-
[[Category: Persson, C.]]
+
[[Category: Sagemark J]]
-
[[Category: SGC, Structural Genomics Consortium.]]
+
[[Category: Schueler H]]
-
[[Category: Sagemark, J.]]
+
[[Category: Thorsell AG]]
-
[[Category: Schueler, H.]]
+
[[Category: Tresaugues L]]
-
[[Category: Thorsell, A G.]]
+
[[Category: Van Den Berg S]]
-
[[Category: Tresaugues, L.]]
+
[[Category: Weigelt J]]
-
[[Category: Weigelt, J.]]
+
[[Category: Welin M]]
-
[[Category: Welin, M.]]
+
[[Category: Wikstrom M]]
-
[[Category: Wikstrom, M.]]
+
[[Category: Wisniewska M]]
-
[[Category: Wisniewska, M.]]
+
-
[[Category: Cytoplasm]]
+
-
[[Category: Ph domain-like]]
+
-
[[Category: Phosphoprotein]]
+
-
[[Category: Pid domain]]
+
-
[[Category: Sgc]]
+
-
[[Category: Signaling protein]]
+
-
[[Category: Structural genomic]]
+
-
[[Category: Structural genomics consortium]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 5 13:07:15 2008''
+

Current revision

Human NUMB-like protein, phosphotyrosine interaction domain

PDB ID 3f0w

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3f0w"
Personal tools