2jln

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{{Seed}}
 
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[[Image:2jln.png|left|200px]]
 
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==Structure of Mhp1, a nucleobase-cation-symport-1 family transporter==
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The line below this paragraph, containing "STRUCTURE_2jln", creates the "Structure Box" on the page.
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<StructureSection load='2jln' size='340' side='right'caption='[[2jln]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2jln]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Microbacterium_liquefaciens Microbacterium liquefaciens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JLN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JLN FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.85&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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{{STRUCTURE_2jln| PDB=2jln | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jln FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jln OCA], [https://pdbe.org/2jln PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jln RCSB], [https://www.ebi.ac.uk/pdbsum/2jln PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jln ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HYUP_MICLQ HYUP_MICLQ] Nucleobase-proton symporter that mediates the sodium-dependent binding and uptake of 5-aryl-substituted hydantoin compounds (PubMed:16621827, PubMed:24952894). 5-indolyl methyl hydantoin and 5-benzyl hydantoin are the preferred substrates, with selectivity for a hydrophobic substituent in position 5 of hydantoin and for the L isomer over the D isomer (PubMed:16621827, PubMed:24952894).<ref>PMID:16621827</ref> <ref>PMID:24952894</ref> <ref>PMID:16116274</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jl/2jln_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jln ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The 'Nucleobase-Cation-Symport-1', NCS1, transporters are essential components of salvage pathways for nucleobases and related metabolites. Here, we report the 2.85 A resolution structure of the NCS1 benzyl-hydantoin transporter, Mhp1, from Microbacterium liquefaciens. Mhp1 contains 12 transmembrane helices, 10 of which are arranged in two inverted repeats of 5 helices. The structures of the outward-facing open and substrate-bound occluded conformations were solved, showing how the outward-facing cavity closes upon binding of substrate. Comparisons with the leucine (LeuTAa) and the galactose (vSGLT) transporters reveal that the outward- and inward-facing cavities are symmetrically arranged on opposite sides of the membrane. The reciprocal opening and closing of these cavities is synchronised by the inverted repeat helices 3 and 8, providing the structural basis of the 'alternating access' model for membrane transport.
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===STRUCTURE OF MHP1, A NUCLEOBASE-CATION-SYMPORT-1 FAMILY TRANSPORTER===
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Structure and Molecular Mechanism of a Nucleobase-Cation-Symport-1 Family Transporter.,Weyand S, Shimamura T, Yajima S, Suzuki S, Mirza O, Krusong K, Carpenter EP, Rutherford NG, Hadden JM, O'Reilly J, Ma P, Saidijam M, Patching SG, Hope RJ, Norbertczak HT, Roach PC, Iwata S, Henderson PJ, Cameron AD Science. 2008 Oct 16. PMID:18927357<ref>PMID:18927357</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_18927357}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2jln" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 18927357 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_18927357}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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2JLN is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Microbacterium_liquefaciens Microbacterium liquefaciens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JLN OCA].
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==Reference==
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Structure and Molecular Mechanism of a Nucleobase-Cation-Symport-1 Family Transporter., Weyand S, Shimamura T, Yajima S, Suzuki S, Mirza O, Krusong K, Carpenter EP, Rutherford NG, Hadden JM, O'Reilly J, Ma P, Saidijam M, Patching SG, Hope RJ, Norbertczak HT, Roach PC, Iwata S, Henderson PJ, Cameron AD, Science. 2008 Oct 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18927357 18927357]
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[[Category: Microbacterium liquefaciens]]
[[Category: Microbacterium liquefaciens]]
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[[Category: Cameron, A D.]]
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[[Category: Cameron AD]]
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[[Category: Carpenter, E P.]]
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[[Category: Carpenter EP]]
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[[Category: Hadden, J M.]]
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[[Category: Hadden JM]]
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[[Category: Henderson, P J.F.]]
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[[Category: Henderson PJF]]
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[[Category: Hope, R J.]]
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[[Category: Hope RJ]]
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[[Category: Iwata, S.]]
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[[Category: Iwata S]]
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[[Category: Krusong, K.]]
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[[Category: Krusong K]]
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[[Category: Ma, P.]]
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[[Category: Ma P]]
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[[Category: Mirza, O.]]
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[[Category: Mirza O]]
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[[Category: Norbertczak, H T.]]
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[[Category: Norbertczak HT]]
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[[Category: Patching, S G.]]
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[[Category: O'Reilly J]]
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[[Category: Reilly, J O.]]
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[[Category: Patching SG]]
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[[Category: Roach, P C.J.]]
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[[Category: Roach PCJ]]
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[[Category: Rutherford, N G.]]
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[[Category: Rutherford NG]]
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[[Category: Saidijam, M.]]
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[[Category: Saidijam M]]
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[[Category: Shimamura, T.]]
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[[Category: Shimamura T]]
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[[Category: Suzuki, S.]]
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[[Category: Suzuki S]]
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[[Category: Weyand, S.]]
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[[Category: Weyand S]]
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[[Category: Yajima, S.]]
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[[Category: Yajima S]]
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[[Category: Hydantoin]]
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[[Category: Membrane protein]]
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[[Category: Nucleobase-cation-symport-1 family]]
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[[Category: Transporter]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 12 10:00:29 2008''
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Current revision

Structure of Mhp1, a nucleobase-cation-symport-1 family transporter

PDB ID 2jln

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