3d5q

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{{Seed}}
 
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[[Image:3d5q.png|left|200px]]
 
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==Crystal Structure of 11b-HSD1 in Complex with Triazole Inhibitor==
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The line below this paragraph, containing "STRUCTURE_3d5q", creates the "Structure Box" on the page.
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<StructureSection load='3d5q' size='340' side='right'caption='[[3d5q]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3d5q]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D5Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3D5Q FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.55&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=T30:3-[1-(4-FLUOROPHENYL)CYCLOPROPYL]-4-(1-METHYLETHYL)-5-[4-(TRIFLUOROMETHOXY)PHENYL]-4H-1,2,4-TRIAZOLE'>T30</scene></td></tr>
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{{STRUCTURE_3d5q| PDB=3d5q | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3d5q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d5q OCA], [https://pdbe.org/3d5q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3d5q RCSB], [https://www.ebi.ac.uk/pdbsum/3d5q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3d5q ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/DHI1_HUMAN DHI1_HUMAN] Defects in HSD11B1 are a cause of cortisone reductase deficiency (CRD) [MIM:[https://omim.org/entry/604931 604931]. In CRD, activation of cortisone to cortisol does not occur, resulting in adrenocorticotropin-mediated androgen excess and a phenotype resembling polycystic ovary syndrome (PCOS).
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== Function ==
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[https://www.uniprot.org/uniprot/DHI1_HUMAN DHI1_HUMAN] Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d5/3d5q_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3d5q ConSurf].
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<div style="clear:both"></div>
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===Crystal Structure of 11b-HSD1 in Complex with Triazole Inhibitor===
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==See Also==
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*[[Hydroxysteroid dehydrogenase 3D structures|Hydroxysteroid dehydrogenase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_18789704}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 18789704 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18789704}}
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==About this Structure==
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3D5Q is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D5Q OCA].
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==Reference==
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Distinctive molecular inhibition mechanisms for selective inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1., Tu H, Powers JP, Liu J, Ursu S, Sudom A, Yan X, Xu H, Meininger D, Degraffenreid M, He X, Jaen JC, Sun D, Labelle M, Yamamoto H, Shan B, Walker NP, Wang Z, Bioorg Med Chem. 2008 Aug 29. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18789704 18789704]
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[[Category: 11-beta-hydroxysteroid dehydrogenase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Liu, J.]]
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[[Category: Large Structures]]
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[[Category: Sudom, A.]]
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[[Category: Liu J]]
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[[Category: Walker, N P.C.]]
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[[Category: Sudom A]]
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[[Category: Wang, Z.]]
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[[Category: Walker NPC]]
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[[Category: 11beta]]
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[[Category: Wang Z]]
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[[Category: Dehydrogenase]]
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[[Category: Endoplasmic reticulum]]
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[[Category: Glycoprotein]]
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[[Category: Hydroxysteroid]]
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[[Category: Lipid metabolism]]
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[[Category: Membrane]]
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[[Category: Microsome]]
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[[Category: Nadp]]
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[[Category: Oxidoreductase]]
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[[Category: Polymorphism]]
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[[Category: Signal-anchor]]
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[[Category: Steroid metabolism]]
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[[Category: Transmembrane]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 12 10:06:57 2008''
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Current revision

Crystal Structure of 11b-HSD1 in Complex with Triazole Inhibitor

PDB ID 3d5q

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