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1tt9

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(New page: 200px<br /><applet load="1tt9" size="450" color="white" frame="true" align="right" spinBox="true" caption="1tt9, resolution 3.42&Aring;" /> '''Structure of the bif...)
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[[Image:1tt9.gif|left|200px]]<br /><applet load="1tt9" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1tt9, resolution 3.42&Aring;" />
 
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'''Structure of the bifunctional and Golgi associated formiminotransferase cyclodeaminase octamer'''<br />
 
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==Overview==
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==Structure of the bifunctional and Golgi associated formiminotransferase cyclodeaminase octamer==
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Mammalian formiminotransferase cyclodeaminase (FTCD), a 0.5 million Dalton, homo-octameric enzyme, plays important roles in coupling histidine, catabolism with folate metabolism and integrating the Golgi complex with, the vimentin intermediate filament cytoskeleton. It is also linked to two, human diseases, autoimmune hepatitis and glutamate formiminotransferase, deficiency. Determination of the FTCD structure by X-ray crystallography, and electron cryomicroscopy revealed that the eight subunits, each, composed of distinct FT and CD domains, are arranged like a square, doughnut. A key finding indicates that coupling of three subunits governs, the octamer-dependent sequential enzyme activities, including channeling, of intermediate and conformational change. The structure further shed, light on the molecular nature of two strong antigenic determinants of FTCD, recognized by autoantibodies from patients with autoimmune hepatitis and, on the binding of thin vimentin filaments to the FTCD octamer.
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<StructureSection load='1tt9' size='340' side='right'caption='[[1tt9]], [[Resolution|resolution]] 3.42&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1tt9]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TT9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TT9 FirstGlance]. <br>
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1TT9 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1TT9 OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.42&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tt9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tt9 OCA], [https://pdbe.org/1tt9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tt9 RCSB], [https://www.ebi.ac.uk/pdbsum/1tt9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tt9 ProSAT]</span></td></tr>
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Structure of the bifunctional and Golgi-associated formiminotransferase cyclodeaminase octamer., Mao Y, Vyas NK, Vyas MN, Chen DH, Ludtke SJ, Chiu W, Quiocho FA, EMBO J. 2004 Aug 4;23(15):2963-71. Epub 2004 Jul 22. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15272307 15272307]
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FTCD_RAT FTCD_RAT] Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool (By similarity).<ref>PMID:12160147</ref> Binds and promotes bundling of vimentin filaments originating from the Golgi.<ref>PMID:12160147</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tt/1tt9_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tt9 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Single protein]]
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[[Category: Chen DH]]
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[[Category: Chen, D.H.]]
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[[Category: Chiu W]]
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[[Category: Chiu, W.]]
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[[Category: Ludtke SJ]]
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[[Category: Ludtke, S.J.]]
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[[Category: Mao Y]]
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[[Category: Mao, Y.]]
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[[Category: Quiocho FA]]
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[[Category: Quiocho, F.A.]]
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[[Category: Vyas MN]]
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[[Category: Vyas, M.N.]]
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[[Category: Vyas NK]]
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[[Category: Vyas, N.K.]]
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[[Category: hepatitis autoantigen]]
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[[Category: intermediate channeling]]
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[[Category: protein assembly]]
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[[Category: structure]]
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[[Category: vimentin]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 03:34:36 2007''
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Current revision

Structure of the bifunctional and Golgi associated formiminotransferase cyclodeaminase octamer

PDB ID 1tt9

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