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3ba8

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{{Seed}}
 
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[[Image:3ba8.jpg|left|200px]]
 
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==Structural Basis for the Inhibition of Bacterial NAD+ Dependent DNA Ligase==
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The line below this paragraph, containing "STRUCTURE_3ba8", creates the "Structure Box" on the page.
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<StructureSection load='3ba8' size='340' side='right'caption='[[3ba8]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3ba8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BA8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BA8 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3B8:2-AMINO-7-FLUORO-5-OXO-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE'>3B8</scene>, <scene name='pdbligand=NMN:BETA-NICOTINAMIDE+RIBOSE+MONOPHOSPHATE'>NMN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3ba8| PDB=3ba8 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ba8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ba8 OCA], [https://pdbe.org/3ba8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ba8 RCSB], [https://www.ebi.ac.uk/pdbsum/3ba8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ba8 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DNLJ_ENTFA DNLJ_ENTFA] DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ba/3ba8_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ba8 ConSurf].
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<div style="clear:both"></div>
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===Structural Basis for the Inhibition of Bacterial NAD+ Dependent DNA Ligase===
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==See Also==
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*[[DNA ligase 3D structures|DNA ligase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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3BA8 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BA8 OCA].
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[[Category: Enterococcus faecalis]]
[[Category: Enterococcus faecalis]]
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[[Category: Pinko, C.]]
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[[Category: Large Structures]]
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[[Category: Adenylation domain]]
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[[Category: Pinko C]]
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[[Category: Dna damage]]
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[[Category: Dna repair]]
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[[Category: Dna replication]]
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[[Category: Ligase]]
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[[Category: Nad]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 12 10:44:57 2008''
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Current revision

Structural Basis for the Inhibition of Bacterial NAD+ Dependent DNA Ligase

PDB ID 3ba8

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