3bnv

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{{Seed}}
 
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[[Image:3bnv.png|left|200px]]
 
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==Crystal structure of Cj0977, a sigma28-regulated virulence protein from Campylobacter jejuni.==
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The line below this paragraph, containing "STRUCTURE_3bnv", creates the "Structure Box" on the page.
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<StructureSection load='3bnv' size='340' side='right'caption='[[3bnv]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3bnv]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Campylobacter_jejuni Campylobacter jejuni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BNV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BNV FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_3bnv| PDB=3bnv | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bnv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bnv OCA], [https://pdbe.org/3bnv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bnv RCSB], [https://www.ebi.ac.uk/pdbsum/3bnv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bnv ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q0R4E3_CAMJU Q0R4E3_CAMJU]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bn/3bnv_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bnv ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Campylobacter jejuni, a Gram-negative motile bacterium, is a leading cause of human gastrointestinal infections. Although the mechanism of C.jejuni-mediated enteritis appears to be multifactorial, flagella play complex roles in the virulence of this human pathogen. Cj0977 is a recently identified virulence factor in C. jejuni and is expressed by a sigma(28) promoter that controls late genes in the flagellar regulon. A Cj0977 mutant strain is fully motile but significantly reduced in the invasion of intestinal epithelial cells in vitro. Here, we report the crystal structure of the major structural domain of Cj0977, which reveals a homodimeric "hot-dog" fold architecture. Of note, the characteristic hot-dog fold has been found in various coenzyme A (CoA) compound binding proteins with numerous oligomeric states. Structural comparison with other known hot-dog fold proteins locates a putative binding site for an acyl-CoA compound in the Cj0977 protein. Structure-based site-directed mutagenesis followed by invasion assays indicates that key residues in the putative binding site are indeed essential for the Cj0977 virulence function, suggesting a possible function of Cj0977 as an acyl-CoA binding regulatory protein.
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===Crystal structure of Cj0977, a sigma28-regulated virulence protein from Campylobacter jejuni.===
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Structure of a sigma28-regulated nonflagellar virulence protein from Campylobacter jejuni.,Yokoyama T, Paek S, Ewing CP, Guerry P, Yeo HJ J Mol Biol. 2008 Dec 12;384(2):364-76. Epub 2008 Sep 23. PMID:18835274<ref>PMID:18835274</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_18835274}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 3bnv" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 18835274 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_18835274}}
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__TOC__
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</StructureSection>
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==About this Structure==
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3BNV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Campylobacter_jejuni Campylobacter jejuni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BNV OCA].
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==Reference==
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Structure of a sigma(28)-Regulated Nonflagellar Virulence Protein from Campylobacter jejuni., Yokoyama T, Paek S, Ewing CP, Guerry P, Yeo HJ, J Mol Biol. 2008 Sep 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18835274 18835274]
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[[Category: Campylobacter jejuni]]
[[Category: Campylobacter jejuni]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Yeo, H J.]]
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[[Category: Yeo HJ]]
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[[Category: Yokoyama, T.]]
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[[Category: Yokoyama T]]
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[[Category: Campylobacter jejuni]]
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[[Category: Flagella]]
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[[Category: Hot-dog fold]]
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[[Category: Unknown function]]
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[[Category: Virulence factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 12 20:12:13 2008''
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Current revision

Crystal structure of Cj0977, a sigma28-regulated virulence protein from Campylobacter jejuni.

PDB ID 3bnv

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