3e1u

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{{Seed}}
 
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[[Image:3e1u.png|left|200px]]
 
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==The Crystal Structure of the Anti-Viral APOBEC3G Catalytic Domain==
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The line below this paragraph, containing "STRUCTURE_3e1u", creates the "Structure Box" on the page.
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<StructureSection load='3e1u' size='340' side='right'caption='[[3e1u]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3e1u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E1U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3E1U FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3e1u| PDB=3e1u | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e1u OCA], [https://pdbe.org/3e1u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e1u RCSB], [https://www.ebi.ac.uk/pdbsum/3e1u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e1u ProSAT]</span></td></tr>
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</table>
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===The Crystal Structure of the Anti-Viral APOBEC3G Catalytic Domain===
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== Function ==
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[https://www.uniprot.org/uniprot/ABC3G_HUMAN ABC3G_HUMAN] DNA deaminase (cytidine deaminase) that mediates a form of innate resistance to retroviral infections (at least to HIV-1 infection) by triggering G-to-A hypermutation in the newly synthesized viral DNA. The replacements C-to-U in the minus strand DNA of HIV-1 during reverse transcription, leads to G-to-A transitions in the plus strand. The inhibition of viral replication is either due to the degradation of the minus strand before its integration or to the lethality of the hypermutations. Modification of both DNA strands is not excluded. This antiviral activity is neutralized by the virion infectivity factor (VIF), that prevents the incorporation of APOBEC3G into progeny HIV-1 virions by both inhibiting its translation and/or by inducing its ubiquitination and subsequent degradation by the 26S proteasome. May also prevent the transposition of a subset of retroelements. Binds a variety of RNAs, but does not display detectable APOB, NF1 and NAT1 mRNA editing.<ref>PMID:14557625</ref> <ref>PMID:12167863</ref> <ref>PMID:12808466</ref> <ref>PMID:12809610</ref> <ref>PMID:12808465</ref> <ref>PMID:12859895</ref> <ref>PMID:12970355</ref> <ref>PMID:14528300</ref> <ref>PMID:15031497</ref> <ref>PMID:16527742</ref> <ref>PMID:21123384</ref> <ref>PMID:18288108</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_18849968}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 18849968 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e1/3e1u_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_18849968}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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3E1U is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E1U OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3e1u ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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Crystal structure of the anti-viral APOBEC3G catalytic domain and functional implications., Holden LG, Prochnow C, Chang YP, Bransteitter R, Chelico L, Sen U, Stevens RC, Goodman MF, Chen XS, Nature. 2008 Nov 6;456(7218):121-4. Epub 2008 Oct 12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18849968 18849968]
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Bransteitter, R.]]
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[[Category: Bransteitter R]]
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[[Category: Chang, Y P.]]
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[[Category: Chang YP]]
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[[Category: Chelico, L.]]
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[[Category: Chelico L]]
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[[Category: Chen, X S.]]
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[[Category: Chen XS]]
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[[Category: Goodman, R F.]]
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[[Category: Goodman RF]]
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[[Category: Holden, L.]]
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[[Category: Holden L]]
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[[Category: Prochnow, C.]]
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[[Category: Prochnow C]]
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[[Category: Sen, U.]]
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[[Category: Sen U]]
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[[Category: Stevens, R C.]]
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[[Category: Stevens RC]]
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[[Category: Alternative splicing]]
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[[Category: Antiviral defense]]
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[[Category: Cytoplasm]]
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[[Category: Five beta-strands surrounded by six alpha-helice]]
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[[Category: Host-virus interaction]]
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[[Category: Hydrolase]]
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[[Category: Metal-binding]]
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[[Category: Nucleus]]
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[[Category: Polymorphism]]
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[[Category: Ubl conjugation]]
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[[Category: Zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 12 20:29:53 2008''
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Current revision

The Crystal Structure of the Anti-Viral APOBEC3G Catalytic Domain

PDB ID 3e1u

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