1mi1

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{{Seed}}
 
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[[Image:1mi1.png|left|200px]]
 
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==Crystal Structure of the PH-BEACH Domain of Human Neurobeachin==
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The line below this paragraph, containing "STRUCTURE_1mi1", creates the "Structure Box" on the page.
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<StructureSection load='1mi1' size='340' side='right'caption='[[1mi1]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1mi1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MI1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MI1 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_1mi1| PDB=1mi1 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mi1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mi1 OCA], [https://pdbe.org/1mi1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mi1 RCSB], [https://www.ebi.ac.uk/pdbsum/1mi1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mi1 ProSAT], [https://www.topsan.org/Proteins/NESGC/1mi1 TOPSAN]</span></td></tr>
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</table>
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===Crystal Structure of the PH-BEACH Domain of Human Neurobeachin===
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== Function ==
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[https://www.uniprot.org/uniprot/NBEA_HUMAN NBEA_HUMAN] Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins (By similarity).[UniProtKB:Q9EPN1]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 12234919 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mi/1mi1_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_12234919}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1MI1 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MI1 OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mi1 ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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Crystal structure of the BEACH domain reveals an unusual fold and extensive association with a novel PH domain., Jogl G, Shen Y, Gebauer D, Li J, Wiegmann K, Kashkar H, Kronke M, Tong L, EMBO J. 2002 Sep 16;21(18):4785-95. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12234919 12234919]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Gebauer, D.]]
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[[Category: Large Structures]]
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[[Category: Jogl, G.]]
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[[Category: Gebauer D]]
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[[Category: Kashkar, H.]]
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[[Category: Jogl G]]
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[[Category: Kroenke, M.]]
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[[Category: Kashkar H]]
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[[Category: Li, J.]]
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[[Category: Kroenke M]]
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[[Category: NESG, Northeast Structural Genomics Consortium.]]
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[[Category: Li J]]
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[[Category: Shen, Y.]]
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[[Category: Shen Y]]
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[[Category: Tong, L.]]
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[[Category: Tong L]]
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[[Category: Wiegmann, K.]]
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[[Category: Wiegmann K]]
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[[Category: Beach domain]]
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[[Category: Nesg]]
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[[Category: Northeast structural genomics consortium]]
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[[Category: Ph domain]]
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[[Category: Protein structure initiative]]
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[[Category: Psi]]
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[[Category: Signal transduction]]
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[[Category: Structural genomic]]
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[[Category: Vesicle trafficking]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Nov 16 09:45:20 2008''
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Current revision

Crystal Structure of the PH-BEACH Domain of Human Neurobeachin

PDB ID 1mi1

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