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1t70

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{{Seed}}
 
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[[Image:1t70.png|left|200px]]
 
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==Crystal structure of a novel phosphatase from Deinococcus radiodurans==
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The line below this paragraph, containing "STRUCTURE_1t70", creates the "Structure Box" on the page.
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<StructureSection load='1t70' size='340' side='right'caption='[[1t70]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1t70]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Deinococcus_radiodurans_R1 Deinococcus radiodurans R1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T70 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T70 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t70 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t70 OCA], [https://pdbe.org/1t70 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t70 RCSB], [https://www.ebi.ac.uk/pdbsum/1t70 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t70 ProSAT], [https://www.topsan.org/Proteins/BSGC/1t70 TOPSAN]</span></td></tr>
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{{STRUCTURE_1t70| PDB=1t70 | SCENE= }}
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</table>
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== Function ==
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===Crystal structure of a novel phosphatase from Deinococcus radiodurans===
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[https://www.uniprot.org/uniprot/PPDE_DEIRA PPDE_DEIRA] Has a dual activity phosphatase/phosphodiesterase in vitro, with a preference to phosphoenolpyruvate (PEP) and 2',3'-cAMP, respectively. Can also use 2',3'-cGMP, 2',3'-cCMP and various model substrates such as p-nitrophenyl phosphate (pNPP), bis-p-nitrophenyl phosphate (bis-pNPP) and p-nitrophenyl thymidine monophosphate (pNP-TMP).<ref>PMID:17847097</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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The line below this paragraph, {{ABSTRACT_PUBMED_17847097}}, adds the Publication Abstract to the page
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 17847097 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t7/1t70_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_17847097}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t70 ConSurf].
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1T70 is a 8 chains structure of sequences from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans_r1 Deinococcus radiodurans r1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T70 OCA].
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<div style="clear:both"></div>
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== References ==
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==Reference==
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<references/>
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Structural and enzymatic characterization of DR1281: A calcineurin-like phosphoesterase from Deinococcus radiodurans., Shin DH, Proudfoot M, Lim HJ, Choi IK, Yokota H, Yakunin AF, Kim R, Kim SH, Proteins. 2008 Feb 15;70(3):1000-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17847097 17847097]
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__TOC__
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[[Category: Deinococcus radiodurans r1]]
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</StructureSection>
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[[Category: BSGC, Berkeley Structural Genomics Center.]]
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[[Category: Deinococcus radiodurans R1]]
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[[Category: Kim, R.]]
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[[Category: Large Structures]]
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[[Category: Kim, S H.]]
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[[Category: Kim R]]
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[[Category: Shin, D H.]]
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[[Category: Kim SH]]
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[[Category: Wang, W.]]
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[[Category: Shin DH]]
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[[Category: Yokota, H.]]
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[[Category: Wang W]]
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[[Category: Berkeley structural genomics center]]
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[[Category: Yokota H]]
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[[Category: Bsgc]]
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[[Category: Crystal]]
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[[Category: Hydrolase]]
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[[Category: Phosphatase]]
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[[Category: Protein structure initiative]]
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[[Category: Psi]]
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[[Category: Structural genomic]]
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[[Category: X-ray crystallography]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Nov 16 09:52:28 2008''
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Current revision

Crystal structure of a novel phosphatase from Deinococcus radiodurans

PDB ID 1t70

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