2cq2
From Proteopedia
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| - | {{Seed}} | ||
| - | [[Image:2cq2.png|left|200px]] | ||
| - | + | ==solution structure of RNA binding domain in Hypothetical protein LOC91801== | |
| - | + | <StructureSection load='2cq2' size='340' side='right'caption='[[2cq2]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2cq2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CQ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CQ2 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cq2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cq2 OCA], [https://pdbe.org/2cq2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cq2 RCSB], [https://www.ebi.ac.uk/pdbsum/2cq2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cq2 ProSAT], [https://www.topsan.org/Proteins/RSGI/2cq2 TOPSAN]</span></td></tr> | |
| - | + | </table> | |
| - | + | == Function == | |
| - | + | [https://www.uniprot.org/uniprot/ALKB8_HUMAN ALKB8_HUMAN] Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA. Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA. Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys). Required for normal survival after DNA damage. May inhibit apoptosis and promote cell survival and angiogenesis.<ref>PMID:19293182</ref> <ref>PMID:20308323</ref> | |
| - | + | == Evolutionary Conservation == | |
| - | + | [[Image:Consurf_key_small.gif|200px|right]] | |
| - | == | + | Check<jmol> |
| - | + | <jmolCheckbox> | |
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cq/2cq2_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cq2 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Inoue M]] |
| - | [[Category: | + | [[Category: Kigawa T]] |
| - | [[Category: | + | [[Category: Muto Y]] |
| - | [[Category: Shirouzu | + | [[Category: Shirouzu M]] |
| - | [[Category: Terada | + | [[Category: Terada T]] |
| - | [[Category: Tsuda | + | [[Category: Tsuda K]] |
| - | [[Category: Yokoyama | + | [[Category: Yokoyama S]] |
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Current revision
solution structure of RNA binding domain in Hypothetical protein LOC91801
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Categories: Homo sapiens | Large Structures | Inoue M | Kigawa T | Muto Y | Shirouzu M | Terada T | Tsuda K | Yokoyama S
