This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2ejm

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (18:50, 29 May 2024) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:2ejm.png|left|200px]]
 
-
<!--
+
==Solution structure of RUH-072, an apo-biotnyl domain form human acetyl coenzyme A carboxylase==
-
The line below this paragraph, containing "STRUCTURE_2ejm", creates the "Structure Box" on the page.
+
<StructureSection load='2ejm' size='340' side='right'caption='[[2ejm]]' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2ejm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EJM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EJM FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ejm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ejm OCA], [https://pdbe.org/2ejm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ejm RCSB], [https://www.ebi.ac.uk/pdbsum/2ejm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ejm ProSAT], [https://www.topsan.org/Proteins/RSGI/2ejm TOPSAN]</span></td></tr>
-
{{STRUCTURE_2ejm| PDB=2ejm | SCENE= }}
+
</table>
-
 
+
== Disease ==
-
===Solution structure of RUH-072, an apo-biotnyl domain form human acetyl coenzyme A carboxylase===
+
[https://www.uniprot.org/uniprot/MCCA_HUMAN MCCA_HUMAN] Defects in MCCC1 are the cause of methylcrotonoyl-CoA carboxylase 1 deficiency (MCC1D) [MIM:[https://omim.org/entry/210200 210200]. An autosomal recessive disorder of leucine catabolism. The phenotype is variable, ranging from neonatal onset with severe neurological involvement to asymptomatic adults. There is a characteristic organic aciduria with massive excretion of 3-hydroxyisovaleric acid and 3-methylcrotonylglycine, usually in combination with a severe secondary carnitine deficiency.<ref>PMID:11170888</ref> <ref>PMID:11406611</ref> <ref>PMID:11181649</ref> <ref>PMID:22150417</ref>
-
 
+
== Function ==
-
 
+
[https://www.uniprot.org/uniprot/MCCA_HUMAN MCCA_HUMAN]
-
==About this Structure==
+
== Evolutionary Conservation ==
-
2EJM is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EJM OCA].
+
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ej/2ejm_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ejm ConSurf].
 +
<div style="clear:both"></div>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Methylcrotonoyl-CoA carboxylase]]
+
[[Category: Large Structures]]
-
[[Category: Hayashi, F.]]
+
[[Category: Hayashi F]]
-
[[Category: Hirota, H.]]
+
[[Category: Hirota H]]
-
[[Category: Momen, A Z.M Ruhul.]]
+
[[Category: Ruhul Momen AZM]]
-
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
+
[[Category: Yokoyama S]]
-
[[Category: Yokoyama, S.]]
+
-
[[Category: Actyl coa carboxylase]]
+
-
[[Category: Biotin]]
+
-
[[Category: Biotin-requiring enzyme]]
+
-
[[Category: Fatty acid synthesis]]
+
-
[[Category: Ligase]]
+
-
[[Category: National project on protein structural and functional analyse]]
+
-
[[Category: Nppsfa]]
+
-
[[Category: Riken structural genomics/proteomics initiative]]
+
-
[[Category: Rsgi]]
+
-
[[Category: Structural genomic]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Nov 16 10:29:49 2008''
+

Current revision

Solution structure of RUH-072, an apo-biotnyl domain form human acetyl coenzyme A carboxylase

PDB ID 2ejm

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2ejm"
Personal tools