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2yrm

From Proteopedia

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{{Seed}}
 
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[[Image:2yrm.png|left|200px]]
 
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<!--
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==Solution structure of the 1st zf-C2H2 domain from Human B-cell lymphoma 6 protein==
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The line below this paragraph, containing "STRUCTURE_2yrm", creates the "Structure Box" on the page.
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<StructureSection load='2yrm' size='340' side='right'caption='[[2yrm]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2yrm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YRM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YRM FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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-->
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_2yrm| PDB=2yrm | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yrm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yrm OCA], [https://pdbe.org/2yrm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yrm RCSB], [https://www.ebi.ac.uk/pdbsum/2yrm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yrm ProSAT], [https://www.topsan.org/Proteins/RSGI/2yrm TOPSAN]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN] Note=Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions. Note=A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1. Note=A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF.
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== Function ==
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[https://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN] Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.<ref>PMID:9649500</ref> <ref>PMID:18280243</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yr/2yrm_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2yrm ConSurf].
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<div style="clear:both"></div>
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===Solution structure of the 1st zf-C2H2 domain from Human B-cell lymphoma 6 protein===
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==See Also==
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*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]]
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== References ==
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==Disease==
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<references/>
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Known disease associated with this structure: Lymphoma, B-cell OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=109565 109565]]
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__TOC__
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</StructureSection>
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==About this Structure==
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2YRM is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YRM OCA].
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Harada, T.]]
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[[Category: Large Structures]]
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[[Category: Kigawa, T.]]
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[[Category: Harada T]]
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[[Category: Koshiba, S.]]
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[[Category: Kigawa T]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Koshiba S]]
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[[Category: Saito, K.]]
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[[Category: Saito K]]
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[[Category: Tomizawa, T.]]
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[[Category: Tomizawa T]]
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[[Category: Watanabe, S.]]
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[[Category: Watanabe S]]
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[[Category: Yokoyama, S.]]
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[[Category: Yokoyama S]]
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[[Category: Dna binding]]
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[[Category: Gene regulation]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rsgi]]
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[[Category: Structural genomic]]
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[[Category: Zf-c2h2]]
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[[Category: Zinc binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Nov 16 11:00:15 2008''
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Current revision

Solution structure of the 1st zf-C2H2 domain from Human B-cell lymphoma 6 protein

PDB ID 2yrm

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