1tyv

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(New page: 200px<br /><applet load="1tyv" size="450" color="white" frame="true" align="right" spinBox="true" caption="1tyv, resolution 1.8&Aring;" /> '''STRUCTURE OF TAILSPIK...)
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[[Image:1tyv.gif|left|200px]]<br /><applet load="1tyv" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1tyv, resolution 1.8&Aring;" />
 
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'''STRUCTURE OF TAILSPIKE-PROTEIN'''<br />
 
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==Overview==
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==STRUCTURE OF TAILSPIKE-PROTEIN==
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The O-antigenic repeating units of lipopolysaccharides from Salmonella, serogroups A, B, and D1 serve as receptors for the phage P22 tailspike, protein, which also has receptor destroying endoglycosidase, (endorhamnosidase) activity, integrating the functions of both, hemagglutinin and neuraminidase in influenza virus. Crystal structures of, the tailspike protein in complex with oligosaccharides, comprising two, O-antigenic repeating units from Salmonella typhimurium, Salmonella, enteritidis, and Salmonella typhi 253Ty were determined at 1.8 A, resolution. The active-site topology with Asp-392, Asp-395, and Glu-359 as, catalytic residues was identified. Kinetics of binding and cleavage, suggest a role of the receptor destroying endorhamnosidase activity, primarily for detachment of newly assembled phages.
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<StructureSection load='1tyv' size='340' side='right'caption='[[1tyv]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1tyv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_virus_P22 Salmonella virus P22]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TYV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TYV FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tyv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tyv OCA], [https://pdbe.org/1tyv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tyv RCSB], [https://www.ebi.ac.uk/pdbsum/1tyv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tyv ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FIBER_BPP22 FIBER_BPP22] Structural component of the short non-contractile tail. The tail comprises six fibers that mediate primary attachment to the host cell lipopolysaccharides (LPS) and display endorhamnosidase enzymatic activity, hydrolyzing the alpha-1,3-O-glycosidic linkage between rhamnose and galactose of the O-antigen polysaccharide. Digestion of the LPS brings the capsid near the cell outer membrane.<ref>PMID:12837775</ref> <ref>PMID:20817910</ref>
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==About this Structure==
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==See Also==
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1TYV is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Yersinia_phage_py54 Yersinia phage py54]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1TYV OCA].
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*[[Tailspike protein 3D structures|Tailspike protein 3D structures]]
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== References ==
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==Reference==
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<references/>
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Crystal structure of phage P22 tailspike protein complexed with Salmonella sp. O-antigen receptors., Steinbacher S, Baxa U, Miller S, Weintraub A, Seckler R, Huber R, Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):10584-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8855221 8855221]
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__TOC__
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[[Category: Single protein]]
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</StructureSection>
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[[Category: Yersinia phage py54]]
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[[Category: Large Structures]]
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[[Category: Huber, R.]]
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[[Category: Salmonella virus P22]]
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[[Category: Steinbacher, S.]]
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[[Category: Huber R]]
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[[Category: binding protein lipopolysaccharide]]
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[[Category: Steinbacher S]]
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[[Category: cell receptor]]
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[[Category: complex]]
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[[Category: endoglycosidase carbohydrate]]
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[[Category: receptor]]
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[[Category: recognition]]
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[[Category: viral adhesion protein]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 03:42:27 2007''
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Current revision

STRUCTURE OF TAILSPIKE-PROTEIN

PDB ID 1tyv

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