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1tzd

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(New page: 200px<br /><applet load="1tzd" size="450" color="white" frame="true" align="right" spinBox="true" caption="1tzd, resolution 2.20&Aring;" /> '''CRYSTAL STRUCTURE OF...)
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[[Image:1tzd.jpg|left|200px]]<br /><applet load="1tzd" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1tzd, resolution 2.20&Aring;" />
 
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'''CRYSTAL STRUCTURE OF THE CATALYTIC CORE OF INOSITOL 1,4,5-TRISPHOSPHATE 3-KINASE'''<br />
 
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==Overview==
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==CRYSTAL STRUCTURE OF THE CATALYTIC CORE OF INOSITOL 1,4,5-TRISPHOSPHATE 3-KINASE==
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Soluble inositol polyphosphates are ubiquitous second messengers in, eukaryotes, and their levels are regulated by an array of specialized, kinases. The structure of an archetypal member of this class, inositol, 1,4,5-trisphosphate 3-kinase (IP3K), has been determined at 2.2 angstroms, resolution in complex with magnesium and adenosine diphosphate. IP3K, contains a catalytic domain that is a variant of the protein kinase, superfamily, and a novel four-helix substrate binding domain. The two, domains are in an open conformation with respect to each other, suggesting, that substrate recognition and catalysis by IP3K involves a dynamic, conformational cycle. The unique helical domain of IP3K blocks access to, the active site by membrane-bound phosphoinositides, explaining the, structural basis for soluble inositol polyphosphate specificity.
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<StructureSection load='1tzd' size='340' side='right'caption='[[1tzd]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1tzd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TZD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TZD FirstGlance]. <br>
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1TZD is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with MG and ADP as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Inositol-trisphosphate_3-kinase Inositol-trisphosphate 3-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.127 2.7.1.127] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1TZD OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tzd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tzd OCA], [https://pdbe.org/1tzd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tzd RCSB], [https://www.ebi.ac.uk/pdbsum/1tzd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tzd ProSAT]</span></td></tr>
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Crystal structure of the catalytic core of inositol 1,4,5-trisphosphate 3-kinase., Miller GJ, Hurley JH, Mol Cell. 2004 Sep 10;15(5):703-11. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15350215 15350215]
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</table>
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[[Category: Inositol-trisphosphate 3-kinase]]
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== Function ==
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[https://www.uniprot.org/uniprot/IP3KA_RAT IP3KA_RAT]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tz/1tzd_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tzd ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Single protein]]
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[[Category: Hurley JH]]
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[[Category: Hurley, J.H.]]
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[[Category: Miller GJ]]
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[[Category: Miller, G.J.]]
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[[Category: ADP]]
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[[Category: MG]]
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[[Category: inositol kinase]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 03:43:14 2007''
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Current revision

CRYSTAL STRUCTURE OF THE CATALYTIC CORE OF INOSITOL 1,4,5-TRISPHOSPHATE 3-KINASE

PDB ID 1tzd

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