2juf

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{{Seed}}
 
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[[Image:2juf.png|left|200px]]
 
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==NMR solution structure of PARC CPH Domain. NESG Target HR3443B/SGC-Toronto==
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The line below this paragraph, containing "STRUCTURE_2juf", creates the "Structure Box" on the page.
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<StructureSection load='2juf' size='340' side='right'caption='[[2juf]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2juf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JUF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JUF FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2juf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2juf OCA], [https://pdbe.org/2juf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2juf RCSB], [https://www.ebi.ac.uk/pdbsum/2juf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2juf ProSAT], [https://www.topsan.org/Proteins/NESGC/2juf TOPSAN]</span></td></tr>
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{{STRUCTURE_2juf| PDB=2juf | SCENE= }}
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</table>
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== Function ==
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===NMR solution structure of PARC CPH Domain. NESG Target HR3443B/SGC-Toronto===
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[https://www.uniprot.org/uniprot/CUL9_HUMAN CUL9_HUMAN] Core component of a Cul9-RING ubiquitin-protein ligase complex, a complex that mediates ubiquitination and subsequent degradation of BIRC5 and is required to maintain microtubule dynamics and genome integrity. Acts downstream of the 3M complex, which inhibits CUL9 activity, leading to prevent ubiquitination of BIRC5 (PubMed:24793696). Cytoplasmic anchor protein in p53/TP53-associated protein complex. Regulates the subcellular localization of p53/TP53 and subsequent function (PubMed:12526791, PubMed:17332328).<ref>PMID:12526791</ref> <ref>PMID:17332328</ref> <ref>PMID:24793696</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==About this Structure==
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Check<jmol>
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2JUF is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JUF OCA].
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ju/2juf_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2juf ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Large Structures]]
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[[Category: Dhe-Paganon, S.]]
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[[Category: Arrowsmith CH]]
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[[Category: Duan, S.]]
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[[Category: Dhe-Paganon S]]
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[[Category: Edwards, A M.]]
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[[Category: Duan S]]
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[[Category: Karra, M.]]
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[[Category: Edwards AM]]
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[[Category: Kaustov, L.]]
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[[Category: Karra M]]
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[[Category: Lemak, S.]]
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[[Category: Kaustov L]]
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[[Category: Liao, J C.C.]]
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[[Category: Lemak S]]
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[[Category: Muhandiram, R.]]
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[[Category: Liao JCC]]
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[[Category: NESG, Northeast Structural Genomics Consortium.]]
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[[Category: Muhandiram R]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Srisailam SH]]
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[[Category: Srisailam, S H.]]
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[[Category: Sundstrom M]]
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[[Category: Sundstrom, M.]]
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[[Category: Weigelt J]]
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[[Category: Weigelt, J.]]
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[[Category: Alternative splicing]]
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[[Category: Atp-binding]]
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[[Category: Coiled coil]]
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[[Category: Cph domain]]
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[[Category: Cytoplasm]]
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[[Category: Gene regulation]]
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[[Category: Metal-binding]]
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[[Category: Nesg]]
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[[Category: Northeast structural genomics consortium]]
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[[Category: Nucleotide-binding]]
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[[Category: Protein structure initiative]]
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[[Category: Psi-2]]
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[[Category: Sgc]]
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[[Category: Structural genomics consortium]]
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[[Category: Ubl conjugation]]
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[[Category: Ubl conjugation pathway]]
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[[Category: Zinc]]
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[[Category: Zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Nov 16 12:09:05 2008''
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Current revision

NMR solution structure of PARC CPH Domain. NESG Target HR3443B/SGC-Toronto

PDB ID 2juf

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