2zcw

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{{Seed}}
 
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[[Image:2zcw.png|left|200px]]
 
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==Crystal Structure of TTHA1359, a Transcriptional Regulator, CRP/FNR family from Thermus thermophilus HB8==
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The line below this paragraph, containing "STRUCTURE_2zcw", creates the "Structure Box" on the page.
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<StructureSection load='2zcw' size='340' side='right'caption='[[2zcw]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2zcw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"flavobacterium_thermophilum"_yoshida_and_oshima_1971 "flavobacterium thermophilum" yoshida and oshima 1971]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2coh 2coh]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZCW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2ZCW FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_2zcw| PDB=2zcw | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2zcw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zcw OCA], [http://pdbe.org/2zcw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zcw RCSB], [http://www.ebi.ac.uk/pdbsum/2zcw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2zcw ProSAT], [http://www.topsan.org/Proteins/RSGI/2zcw TOPSAN]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zc/2zcw_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zcw ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Thermus thermophilus SdrP is one of four cyclic AMP receptor protein (CRP)/fumarate and nitrate reduction regulator (FNR) family proteins from the extremely thermophilic bacterium T. thermophilus HB8. Expression of sdrP mRNA increased in the stationary phase during cultivation at 70 degrees C. Although the sdrP gene was non-essential, an sdrP-deficient strain showed growth defects, particularly when grown in a synthetic medium, and increased sensitivity to disulphide stress. The expression of several genes was altered in the sdrP disruptant. Among them, we found eight SdrP-dependent promoters using in vitro transcription assays. A predicted SdrP binding site similar to that recognized by Escherichia coli CRP was found upstream of each SdrP-dependent promoter. In the wild-type strain, expression of these eight genes tended to increase upon entry into the stationary phase. Transcriptional activation in vitro was independent of any added effector molecule. The hypothesis that apo-SdrP is the active form of the protein was supported by the observation that the three-dimensional structure of apo-SdrP is similar to that of the DNA-binding form of E. coli CRP. Based on the properties of the SdrP-regulated genes found in this study, it is speculated that SdrP is involved in nutrient and energy supply, redox control, and polyadenylation of mRNA.
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===Crystal Structure of TTHA1359, a Transcriptional Regulator, CRP/FNR family from Thermus thermophilus HB8===
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Global gene expression mediated by Thermus thermophilus SdrP, a CRP/FNR family transcriptional regulator.,Agari Y, Kashihara A, Yokoyama S, Kuramitsu S, Shinkai A Mol Microbiol. 2008 Oct;70(1):60-75. Epub 2008 Aug 11. PMID:18699868<ref>PMID:18699868</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_18699868}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2zcw" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 18699868 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_18699868}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Flavobacterium thermophilum yoshida and oshima 1971]]
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2ZCW is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2coh 2coh]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZCW OCA].
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[[Category: Large Structures]]
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[[Category: Agari, Y]]
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==Reference==
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[[Category: Kuramitsu, S]]
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Global gene expression mediated by Thermus thermophilus SdrP, a CRP/FNR family transcriptional regulator., Agari Y, Kashihara A, Yokoyama S, Kuramitsu S, Shinkai A, Mol Microbiol. 2008 Aug 11. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18699868 18699868]
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[[Category: Structural genomic]]
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[[Category: Thermus thermophilus]]
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[[Category: Yokoyama, S]]
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[[Category: Agari, Y.]]
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[[Category: Kuramitsu, S.]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Yokoyama, S.]]
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[[Category: Camp-binding domain]]
[[Category: Camp-binding domain]]
[[Category: Dna-binding]]
[[Category: Dna-binding]]
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[[Category: National project on protein structural and functional analyse]]
[[Category: National project on protein structural and functional analyse]]
[[Category: Nppsfa]]
[[Category: Nppsfa]]
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[[Category: Riken structural genomics/proteomics initiative]]
 
[[Category: Rsgi]]
[[Category: Rsgi]]
[[Category: Stationary phase]]
[[Category: Stationary phase]]
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[[Category: Structural genomic]]
 
[[Category: Thermus thermophilus]]
[[Category: Thermus thermophilus]]
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[[Category: Transcription]]
[[Category: Transcription regulation]]
[[Category: Transcription regulation]]
[[Category: Transcriptional regulator]]
[[Category: Transcriptional regulator]]
[[Category: Winged helix dna-binding domain]]
[[Category: Winged helix dna-binding domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Nov 16 12:53:31 2008''
 

Current revision

Crystal Structure of TTHA1359, a Transcriptional Regulator, CRP/FNR family from Thermus thermophilus HB8

PDB ID 2zcw

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