2doa

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{{Seed}}
 
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[[Image:2doa.png|left|200px]]
 
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==Solution structure of the helical domain in human Eleven-nineteen lysine-rich leukemia protein ELL==
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The line below this paragraph, containing "STRUCTURE_2doa", creates the "Structure Box" on the page.
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<StructureSection load='2doa' size='340' side='right'caption='[[2doa]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2doa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DOA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DOA FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2doa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2doa OCA], [https://pdbe.org/2doa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2doa RCSB], [https://www.ebi.ac.uk/pdbsum/2doa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2doa ProSAT], [https://www.topsan.org/Proteins/RSGI/2doa TOPSAN]</span></td></tr>
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{{STRUCTURE_2doa| PDB=2doa | SCENE= }}
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</table>
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== Disease ==
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===Solution structure of the helical domain in human Eleven-nineteen lysine-rich leukemia protein ELL===
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[https://www.uniprot.org/uniprot/ELL_HUMAN ELL_HUMAN] Note=A chromosomal aberration involving ELL is found in acute leukemias. Translocation t(11;19)(q23;p13.1) with MLL/HRX. The result is a rogue activator protein.
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== Function ==
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[https://www.uniprot.org/uniprot/ELL_HUMAN ELL_HUMAN] Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation complex and early elongation.<ref>PMID:8596958</ref> <ref>PMID:16006523</ref> <ref>PMID:20471948</ref> <ref>PMID:20159561</ref> <ref>PMID:22252557</ref>
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==About this Structure==
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== Evolutionary Conservation ==
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2DOA is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DOA OCA].
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/do/2doa_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2doa ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Inoue, M.]]
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[[Category: Large Structures]]
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[[Category: Kigawa, T.]]
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[[Category: Inoue M]]
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[[Category: Koshiba, S.]]
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[[Category: Kigawa T]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Koshiba S]]
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[[Category: Saito, K.]]
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[[Category: Saito K]]
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[[Category: Yokoyama, S.]]
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[[Category: Yokoyama S]]
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[[Category: C19orf17]]
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[[Category: Elongation factor]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rsgi]]
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[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Nov 16 13:03:11 2008''
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Current revision

Solution structure of the helical domain in human Eleven-nineteen lysine-rich leukemia protein ELL

PDB ID 2doa

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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