2yrg

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{{Seed}}
 
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[[Image:2yrg.png|left|200px]]
 
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==Solution structure of the B-box domain from tripartite motif-containing protein 5==
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The line below this paragraph, containing "STRUCTURE_2yrg", creates the "Structure Box" on the page.
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<StructureSection load='2yrg' size='340' side='right'caption='[[2yrg]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2yrg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YRG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YRG FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_2yrg| PDB=2yrg | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yrg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yrg OCA], [https://pdbe.org/2yrg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yrg RCSB], [https://www.ebi.ac.uk/pdbsum/2yrg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yrg ProSAT], [https://www.topsan.org/Proteins/RSGI/2yrg TOPSAN]</span></td></tr>
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</table>
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===Solution structure of the B-box domain from tripartite motif-containing protein 5===
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== Function ==
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[https://www.uniprot.org/uniprot/TRIM5_HUMAN TRIM5_HUMAN] Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3). Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell. Restricts infection by N-tropic murine leukemia virus (N-MLV) and equine infectious anemia virus (EIAV).<ref>PMID:18312418</ref> <ref>PMID:21632761</ref> <ref>PMID:12878161</ref> <ref>PMID:16474118</ref> <ref>PMID:16643975</ref> <ref>PMID:21512573</ref> <ref>PMID:21035162</ref> <ref>PMID:22291694</ref>
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== Evolutionary Conservation ==
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==About this Structure==
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[[Image:Consurf_key_small.gif|200px|right]]
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2YRG is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YRG OCA].
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yr/2yrg_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2yrg ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Hayahsi, F.]]
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[[Category: Large Structures]]
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[[Category: Qin, X R.]]
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[[Category: Hayahsi F]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Qin XR]]
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[[Category: Yokoyama, S.]]
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[[Category: Yokoyama S]]
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[[Category: B-box domain]]
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[[Category: Ligase]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Ring finger protein 88]]
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[[Category: Rsgi]]
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[[Category: Structural genomic]]
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[[Category: Tripartite motif-containing protein 5]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Nov 16 13:49:01 2008''
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Current revision

Solution structure of the B-box domain from tripartite motif-containing protein 5

PDB ID 2yrg

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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