2dsg

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (05:54, 6 August 2025) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:2dsg.png|left|200px]]
 
-
<!--
+
==Crystal structure of Lys26 to Arg mutant of Diphthine synthase==
-
The line below this paragraph, containing "STRUCTURE_2dsg", creates the "Structure Box" on the page.
+
<StructureSection load='2dsg' size='340' side='right'caption='[[2dsg]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2dsg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_horikoshii_OT3 Pyrococcus horikoshii OT3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DSG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DSG FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
{{STRUCTURE_2dsg| PDB=2dsg | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dsg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dsg OCA], [https://pdbe.org/2dsg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dsg RCSB], [https://www.ebi.ac.uk/pdbsum/2dsg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dsg ProSAT], [https://www.topsan.org/Proteins/RSGI/2dsg TOPSAN]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/DPHB_PYRHO DPHB_PYRHO] S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.<ref>PMID:20873788</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ds/2dsg_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dsg ConSurf].
 +
<div style="clear:both"></div>
-
===Crystal structure of Lys26 to Arg mutant of Diphthine synthase===
+
==See Also==
-
 
+
*[[Diphthine synthase|Diphthine synthase]]
-
 
+
== References ==
-
==About this Structure==
+
<references/>
-
2DSG is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DSG OCA].
+
__TOC__
-
[[Category: Diphthine synthase]]
+
</StructureSection>
-
[[Category: Pyrococcus horikoshii]]
+
[[Category: Large Structures]]
-
[[Category: Kumarevel, T S.]]
+
[[Category: Pyrococcus horikoshii OT3]]
-
[[Category: Kunishima, N.]]
+
[[Category: Kumarevel TS]]
-
[[Category: Matsuura, Y.]]
+
[[Category: Kunishima N]]
-
[[Category: Mizutani, H.]]
+
[[Category: Malathy Sony SM]]
-
[[Category: Ponnuswamy, M N.]]
+
[[Category: Matsuura Y]]
-
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
+
[[Category: Mizutani H]]
-
[[Category: Saraboji, K.]]
+
[[Category: Ponnuswamy MN]]
-
[[Category: Sony, S M.Malathy.]]
+
[[Category: Saraboji K]]
-
[[Category: Methyltransferase]]
+
-
[[Category: National project on protein structural and functional analyse]]
+
-
[[Category: Nppsfa]]
+
-
[[Category: Riken structural genomics/proteomics initiative]]
+
-
[[Category: Rsgi]]
+
-
[[Category: Structural genomic]]
+
-
[[Category: Transferase]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Nov 16 13:58:09 2008''
+

Current revision

Crystal structure of Lys26 to Arg mutant of Diphthine synthase

PDB ID 2dsg

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2dsg"
Personal tools