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2enm

From Proteopedia

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{{Seed}}
 
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[[Image:2enm.png|left|200px]]
 
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==Solution structure of the SH3 domain from mouse sorting nexin-9==
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The line below this paragraph, containing "STRUCTURE_2enm", creates the "Structure Box" on the page.
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<StructureSection load='2enm' size='340' side='right'caption='[[2enm]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2enm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ENM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ENM FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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-->
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2enm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2enm OCA], [https://pdbe.org/2enm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2enm RCSB], [https://www.ebi.ac.uk/pdbsum/2enm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2enm ProSAT], [https://www.topsan.org/Proteins/RSGI/2enm TOPSAN]</span></td></tr>
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{{STRUCTURE_2enm| PDB=2enm | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SNX9_MOUSE SNX9_MOUSE] May be involved in several stages of intracellular trafficking. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F-actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/en/2enm_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2enm ConSurf].
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<div style="clear:both"></div>
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===Solution structure of the SH3 domain from mouse sorting nexin-9===
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==See Also==
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*[[Sorting nexin 3D structures|Sorting nexin 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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2ENM is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ENM OCA].
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Hayashi, F.]]
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[[Category: Hayashi F]]
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[[Category: Kurosaki, C.]]
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[[Category: Kurosaki C]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Wakabayashi M]]
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[[Category: Wakabayashi, M.]]
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[[Category: Yokoyama S]]
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[[Category: Yokoyama, S.]]
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[[Category: Yoshida M]]
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[[Category: Yoshida, M.]]
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[[Category: Endocytosis]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Protein transport]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rsgi]]
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[[Category: Sh3-like barrel]]
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[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Nov 16 14:05:01 2008''
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Current revision

Solution structure of the SH3 domain from mouse sorting nexin-9

PDB ID 2enm

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