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1u3i
From Proteopedia
(Difference between revisions)
(New page: 200px<br /><applet load="1u3i" size="450" color="white" frame="true" align="right" spinBox="true" caption="1u3i, resolution 1.89Å" /> '''Crystal structure of...) |
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| - | [[Image:1u3i.gif|left|200px]]<br /><applet load="1u3i" size="450" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="1u3i, resolution 1.89Å" /> | ||
| - | '''Crystal structure of glutathione S-tranferase from Schistosoma mansoni'''<br /> | ||
| - | == | + | ==Crystal structure of glutathione S-tranferase from Schistosoma mansoni== |
| - | + | <StructureSection load='1u3i' size='340' side='right'caption='[[1u3i]], [[Resolution|resolution]] 1.89Å' scene=''> | |
| - | [ | + | == Structural highlights == |
| - | + | <table><tr><td colspan='2'>[[1u3i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Schistosoma_mansoni Schistosoma mansoni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U3I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U3I FirstGlance]. <br> | |
| - | [ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.89Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene></td></tr> | |
| - | [ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u3i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u3i OCA], [https://pdbe.org/1u3i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u3i RCSB], [https://www.ebi.ac.uk/pdbsum/1u3i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u3i ProSAT]</span></td></tr> |
| - | [[ | + | </table> |
| - | + | == Function == | |
| - | + | [https://www.uniprot.org/uniprot/GST28_SCHMA GST28_SCHMA] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. GST isoenzymes appear to play a central role in the parasite detoxification system. Other functions are also suspected including a role in increasing the solubility of haematin in the parasite gut. | |
| - | [ | + | == Evolutionary Conservation == |
| - | [[ | + | [[Image:Consurf_key_small.gif|200px|right]] |
| - | + | Check<jmol> | |
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u3/1u3i_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1u3i ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | + | ==See Also== | |
| + | *[[Glutathione S-transferase 3D structures|Glutathione S-transferase 3D structures]] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Schistosoma mansoni]] | ||
| + | [[Category: Capron A]] | ||
| + | [[Category: Chomilier J]] | ||
| + | [[Category: Labesse G]] | ||
| + | [[Category: Mormon J-P]] | ||
| + | [[Category: Trottein F]] | ||
| + | [[Category: Vaney MC]] | ||
Current revision
Crystal structure of glutathione S-tranferase from Schistosoma mansoni
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